10 Best DIM (Diindolylmethane) Supplements (2024) Reviewed and Compared

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✓ Medically Reviewed and Fact-Checked by Dr. Jesse Ropat, PharmD, RPh, B.Sc.

DIM (Diindolylmethane) is a supplement known for helping balance your main sex hormones: testosterone (man’s main androgen) and estrogen. This, in turn, may have array of benefits, from treating hormonal acne, to alleviating PMS symptoms, to support energy levels and gym performance.

In this article, we’ll discuss if DIM is worth its hype and the best DIM supplements on the market.

What is DIM (Diindolylmethane)?

Diindolylmethane (DIM), a bioactive metabolite of indole-3-carbinol can be obtained by eating cruciferous vegetables. However, in order to get its full health benefit, you would need to eat multiple servings each day. This is why a supplement can be both a handy and effective way to get some DIM into your diet. As a supplement, it may also be useful for targeting certain conditions.

Studies have shown that this compound might reduce the risk of developing certain cancers. It also might help manage levels of estrogen in the body. Several studies are examining its impact on breast cancer, and other estrogen-based cancers. In some patients taking chemotherapy, there was favourable changes in estrogen metabolism and circulating levels of sex-hormone binding globulin (SHBG). This is good news, but we need more evidence to determine its place in clinical therapy.

With that said, let’s take a look at some of our superstar supplements – a list in which we include only the best DIM supplements on the market today.

Th Best DIM (Diindolylmethane) Supplements in 2024

*Note: We do have affiliate links throughout this article, which means we receive a commission if you purchase from any of our links. This supports our mission to bring complicated health and fitness info into an entertaining package. And it keeps us from putting up annoying things like banner ads. Those suck.

1) Slim Sciences DIM+

DIM+ Bottles (Three)

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Slim Sciences DIM+ is at the top of our list because of its quality, transparency, strict testing, and value.

First, let’s talk about their quality. Slim Sciences manufactures its DIM in the USA, in an FDA-approved facility. This strict level of testing isn’t common for supplements, and it affirms the quality. Adjacent to this, their DIM is gluten-free, non-GMO, and vegan.

In addition to 200mg of DIM per serving, Slim Sciences’s formula includes 200mg of broccoli powder, 200mg of cabbage powder, and 150mg of pomegranate extract. These are all natural sources of DIM. 

As for value, because of their quality, it’s typically a bit expensive, but right now Slim Sciences is offering a buy 1, get 2 free deal, making it a great value overall. They also have a 180 money-back guarantee, so there’s no risk if you realize it’s not for you.

For all of these reasons, Slim Sciences DIM+ is our #1 pick in the “best DIM supplement” draft.


Primegenix DIM 3x

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PrimeGENIX formulated DIM3X to provide maximum benefit to its users by selecting only the highest quality ingredients proven to stop the conversion of testosterone into estrogen.

The powerful ingredients that make the DIM3X formula outperform its competition are:

Diindolylmethane (DIM) – DIM has been shown to reduce estrogen levels as well as the adverse effects of estrogen in men. It has also been successful in blocking estrogen production in part because it helps regulate estrogen metabolism.

Bioperine (Black Pepper) – Bioperine is known for boosting the bioavailability of all other ingredients included in a supplement. This means that your body has a better chance of absorbing the nutrients and by extension the benefits, from other active ingredients.

AstraGin – This natural compound is a combination of Astragalus and Ginseng. Astragalus is often used to improve heart health and overall health while Ginseng has been linked to decreasing estrogen levels.

Vitamin E – This vitamin is an antioxidant and has anti-estrogenic properties, which means it helps reduce the negative effects of estrogen on men.

This makes this product more than just a DIM product. It has a nice cocktail for healthy hormonal support.

There are 120 capsules in each bottle of DIM3X, which is enough for a 30-day supply. 

Most users report experiencing noticeable results within four weeks of consistent use. 

The company behind PrimeGENIX DIM3X is Leading Edge Health (LEH), one of the top brands in the supplement industry. LEH is known for producing health supplements that include the highest quality of natural ingredients, as well as for its highly effective products.

The benefits of supplementing with DIM3X are numerous with hardly any drawbacks.

  • Inhibits estrogen production
  • Supports testosterone production
  • Increases fat metabolism
  • Boosts sex drive
  • Reduces the appearance of man boobs
  • Increases energy levels
  • Improves erectile function

DIM3X is manufactured in a cGMP facility in the USA. Production facilities with this certification have been stamped by the FDA as compliant with safe and transparent production methods. Supplements produced in these facilities contain optimal dosages of the listed ingredients and have been tested for quality, purity, and safety.

You can get a discount if you buy enough for three or six months at once. You can also get free shipping in the USA on orders over $200.

Finally, we like that they have a 67-day risk-free trial. If for whatever reason it doesn’t work for you, you can send back the used and unused bottles for a full refund.

The downside is that it is pricier than many other options, which is why it sits at #2.

3) Source Naturals DIM 200 mg

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Source Naturals DIM supplement contains 200 mg of Diindolylmethane, Vitamin E, and a black pepper extract.

Vitamin E works as an antioxidant in the body, while black pepper acts as a digestive aid. Combined, it’s claimed that these ingredients can rid the body of toxins and balance hormones. Plus, the capsule is vegetarian-friendly and it’s non-GMO.

Each bottle contains 30 to 60 servings depending on whether you take 1 to 2 capsules per day. If you’re new to taking DIM and want a dependable supplement, Source Naturals is a good option.

4) NOW Foods DIM 200 mg

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Now Foods offers a high-quality DIM supplement at an affordable cost. It contains Calcium D-Glucarate, which is believed to act as a detoxifying agent, and chlorophyll, which is suggested to stimulate the immune system. Each bottle contains 90 servings if taking the recommended 1 capsule per day. The capsule is also vegetarian-friendly.

5) Jarrow Formulas DIM + CDG

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Jarrow Formulas DIM + CDG supplement contains 100 mg of Diindolylmethane and 250 mg of Calcium D-glucarate. CDG (Calcium D-Glucarate) is suggested to play a role in the detoxification of the body. Combined with DIM, Jarrows suggests that the supplement can help reduce toxins in the body and balance hormonal levels.

The capsule is vegan-friendly and gluten-free, and each bottle contains about 30 servings if taking 1 capsule per day.

6) Nature’s Way DIM Plus

Nature's Way, DIM-plus, Estrogen Metabolism, 120 Vegetarian Capsules

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Nature’s Way DIM uses a patented form called Indolplex® BR-DIM®. They argue that this form may lead to enhanced absorption. It includes 100mg of DIM along with the Protectamins® vegetable blend.

With 120 vegetarian capsules per serving, this is another solid option.

7) Thorne Research DIM Advantage

Thorne DIM advantage

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Thorne Dim Advantage contains naturally sourced ingredients from broccoli and pomegranate in addition to 150 mg of DIM. Combined, these ingredients are suggested to detoxify the body and support hormonal health.

It contains 30 to 60 servings, depending on whether you take 1 or 2 capsules daily. It is also dairy free, soy free, and gluten free, so it’s a good option for alternative diets.

Thorne makes amazing products, so it’s no wonder this is one of the best DIM supplement options on our list.

8) Diindolylmethane (DIM) Powder

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PureBulk DIM is another great option for buying in bulk.

What’s great about PureBulk is that you can choose the kind of supplement (capsule or powder-based) and the container size that you want. In addition, you can mix the powder-based supplement into any shake or beverage.

Both the capsule and powder forms are free of dairy, gluten, soy, and sugar. Overall, it’s a really versatile supplement from a quality company.

9) Effective Nutra DIM + BioPerine

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When it comes to balancing your hormones, not all supplements are created equal. Enter Effective Nutra’s DIM 300mg with BioPerine – a game-changer in the world of hormonal health.

It’s not just about the DIM. It’s about the extra strength 300mg of pure DIM combined with 5mg of BioPerine, ensuring that your body absorbs and utilizes every bit of goodness. This isn’t just a supplement; it’s a two-month journey to hormonal harmony.

Made in the USA, vegan, non-GMO, and third-party tested, Effective Nutra is a quality contender.

10) Nutricost DIM

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With each capsule, you’re getting a powerful dose of 300mg of pure DIM, meticulously crafted to ensure you reap all the benefits this natural compound has to offer. And with a 120-capsule supply, you’re set for months of consistent hormonal support.

Proudly made with the highest standards, every capsule promises purity, potency, and safety. They have a 60-day money back guarantee, and they use an accredited third-party lab to test all of their stuff. 

This isn’t our top choice, but it’s still certainly one of the best DIM supplement options out there.


What Are the Benefits of DIM Supplements?

“Okay, well why you I take a dim supplement?” you may be asking.

First, DIM has been shown to have anticancer effects.

For instance, one study showed that taking 300 mg of DIM for a year increased two types of estrogen levels that may reduce the risk of breast cancer in its participants. Another study found that DIM could potentially be used as a preventative against prostate cancer.

There have been other studies that suggest taking a DIM supplement can protect against ovarian cancer, but more human research is needed.

DIM has also been suggested to help with weight loss, but this is mostly speculative and as a result of improved hormonal balance.

In fact, there is no research that examines DIM’s role in weight loss. However, there are studies that show how unbalanced estrogen levels in the body can lead to weight gain and weight fluctuation. Therefore, managing estrogen levels may help people maintain a healthy weight.

Support Hormone Balance

In a similar light, taking a DIM supplement might help with other hormonal disorders. While there isn’t currently evidence to support this claim, existing studies show that estrogen levels play a significant role in hormonal issues like acne and PMS. A DIM supplement, therefore, might help balance the hormones causing these issues.

If you struggle with hormonal-related issues such as weight gain, PMS, or acne, or you want to take preventative measures against certain cancers, a DIM supplement might be worth the try.

It can also help with hormone-related hot flashes and mood swings.

What is the best time to take a DIM supplement?

Let me give some background for what I’m about to say. There’s an enzyme – CYP1A1. The activity of this enzyme rises and falls during the day in accordance with our circadian rhythm gene, aptly named CLOCK. 

DIM levels can increase the activity of CYP1A1 and promote the metabolism of estrogen, and also promoting anti-inflammatory pathways.

Since we want to try and follow along with the circadian rhythm, it may be worthwhile taking DIM in the morning. This is not a hard-and-fast rule, but might have greater benefit than nighttime dosing.

According to the Denver Vein Center, some women with insomnia due to high estrogen levels, perimenopause, or menopause, might find DIM helps them stay asleep longer – and even through the night.

Does DIM impact kidney health?

AKI, or acute kidney injury, is a common problem in hospitalized and critical patients, and the risks are quite morbid.

In one study, they found that DIM (in mice) was able to attenuate AKI and produced improved kidney outcomes, reducing kidney damage scores, likely through antioxidant pathways, protecting our delicate renal cells.

Does DIM impact acne?

Since estrogen and testosterone are key hormones involved in some forms of acne, it’s absolutely possible that DIM can play a role in acne management. By regulating our levels of SHBG and estrogen, and acting as an aromatase inhibitor, its reasonable to suggest it can reduce some of the impacts of acne, but there are certainly other therapies we would recommend before DIM.

Is DIM for men and women?

Yes. While perhaps more popular for men and testosterone support, DIM is a popular ingredient in women’s health supplements as well.

How much DIM should I take daily?

DIM typically has low bioavailability, so ideally you’re getting a form with some form of absorption enhancement. 

There is a book titled “All About DIM“, they recommend 100 to 200 mg per day for women and 200 to 400 mg of DIM per day for men.

In general, the recommended dose for DIM is 100 mg to 900 mg.

Are there any drawbacks?

DIM (Diindolylmethane) is considered to be a safe supplement. No serious side effects of DIM have been reported. Mild side effects include headaches, gas, and increased bowel movements.

Don’t take it if you take hormone-related medications, as it is unclear how the medication and supplement would interact.

Experiences vary from person to person. If you want a supplement that can help with acne or weight loss, or you want to take a preventative against certain cancers, a DIM supplement is worth a try.

Does DIM affect liver function?

There’s some evidence that DIM alters liver function, to allow more estrogen to be metabolized into its inactive form. DIM does also block some of the effects of estrogen on cells, but this is a bit of messy evidence, because it might also enhance some effects of estrogen.

We simply don’t know enough at the moment.

Can DIM help with menopausal symptoms?

Yes. Because it can help with estrogen balance, its’ popular for women looking to relieve PMS symptoms and menopausal symptoms.

Can I get DIM from food?

Yes, you’ll find DIM naturally in superfoods like broccoli. However, to get the dose you can get easily from supplements, you’d have to pound down the veggies. If you are pounding down the veggies, more power to you and you can likely pass on this supplement, unless you’re taking it for a specific reason.

When you eat and digest cruciferous vegetables, such as broccoli, cauliflower, or brussell sprouts, your body creates a compound called DIM (Diindolylmethane), after which it digresses into another compound called indole-3 carbinol. This was just for all the nerds who make it this far.

How long does DIM take before I notice results?

This is a tricky question. In general, I recommend a reasonable trial – usually on the scale of 4-6 weeks, before you start to judge whether it’s effective.

Disclaimer: We are not doctors and we don’t pretend to be on the internet. Talk to your healthcare provider before taking a DIM supplement, or any dietary supplement.

About the Author

Kelly is a Hawaii-based wellness writer. She graduated with her Master's degree in English and combines her background in health care, wellness, and fitness with her writing background to create content for various health-related companies. In her free time, you'll find her reading on the beach or training for her next half marathon.

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