5 Best Estrogen Blocker Supplements (2024) Reviewed and Compared

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Testosterone often receives the credit for being responsible for men’s ability to gain muscle mass faster than women. More often, estrogen is viewed as a dirty word when discussing muscle building. And for good reason, to some extent.

Excessively high estrogen levels in men can wreak havoc on our bodies and keep workout goals just out of reach. This is one reason bodybuilders seek out ways to block estrogen while also using testosterone boosters.

Natural methods for achieving hormonal balance have been trending recently, and one of the categories that has come up more and more is a group of supplements called “estrogen blockers,” or sometimes called “aromatase inhibitors.”

In this article, we’ll discuss what these are, who should take them, and the best estro supplements on the market today.

Note, the most popular ingredient in these supplements is called “DIM.” We talked about standalone DIM supplements separately in this article on the best DIM supplements. On this list, we include supplements that are more than just simple DIM products.

Why Should You Take Estrogen Blockers?

Estrogen is a hormone that is present in both men and women. Commonly referred to as the “female hormone,” estrogen actually plays a pretty important role in men’s health as well. More surprisingly is that the symptoms of low estrogen are similar to those of high estrogen in men.

Estradiol, the predominant form of estrogen normally found in men, plays a crucial role in male sexual function. What is considered a normal level of estrogen in men will vary depending on your age and overall health. Typically, an adult male should have an estradiol level of 10-40 picograms per milliliter (pg/mL), according to endocrinology studies.

The biggest issues arise when too much estrogen is present in men. Take a look at some of the negative health effects that come when men have above-normal estrogen levels:

  • Prostate cancer
  • Gynecomastia
  • Reduced muscle mass
  • Increased muscle weakness
  • Cardiovascular issues
  • Loss of libido
  • Erectile dysfunction
  • Weight gain
  • Infertility
  • Depression

Increases in estrogen levels may indicate more serious underlying health problems, including diabetes, hyperthyroidism, or cirrhosis. If you are experiencing the symptoms of high estrogen levels, it’s a good idea to speak with your doctor.

You may also find that taking an estrogen blocker supplement can help, as they can reduce the harmful effects of excess estrogen in the body.

How Estrogen Blockers Work

The aromatase enzyme is the key compound that makes estrogen in men. It converts testosterone to estradiol. The enzyme is found in male brain tissue, blood vessels, skin, and testes.

Despite sometimes being called estrogen blockers, these supplements do not block the production of estrogen. They stop the aromatase enzyme from converting testosterone into estrogen.

By regulating the secretion and flow of aromatase from its production gland, they limit the conversion of testosterone into estrogen. The best estrogen blocker supplements rely on natural ingredients that have been scientifically shown to support hormonal balance in men.

Are Estrogen Blockers Supplements Safe?

Certainly, there’s a ton of garbage out there. This is true for supplements in general, but it gets extra sketchy when we start to talk about anything related to sex, sex hormones, and drugs. There are actual drugs which block estrogen. That’s not what we’re talking about here.

There are also tons of sketchy supplements you’d see everywhere from porn ads, to facebook abs.

However, when companies use quality, research-backed ingredients and go through third-party testing (like every product on our list), then yes, they’re safe. The supplements included on our list have no serious side effects associated with them.

As with any new supplement, talk with a healthcare professional to avoid potentially negative interactions. This is especially true for men who have existing medical conditions or are currently taking prescription medications.

The ideal candidates for most estrogen blocker supplements are healthy, active individuals over 18 years. Women who are pregnant or nursing should not take these types of supplements.

The Best 5 Estrogen Blocker Supplements

All right. Time to talk about some products.

*Note: We do have affiliate links throughout this article, which means we receive a commission if you purchase from any of our links. This supports our mission to bring complicated health and fitness info into an entertaining package. And it keeps us from putting up annoying things like banner ads. Those suck.


Primegenix DIM 3x

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PrimeGENIX DIM3X is one of the newest estrogen blockers on the market and it’s already made a huge splash. In addition to blocking the aromatase enzyme from converting testosterone into estrogen, it also works to slow the production of estrogen so that your body can achieve hormonal balance.

Part of what earns DIM3X the top spot on our list, and what sets this supplement apart from the competition, is that it’s one of the only products designed specifically for the average guy. Every guy that goes to the gym regularly doesn’t want to be a bodybuilder. Yet most of the supplements out there are marketed almost exclusively to professionals.

Anyone can benefit from taking PrimeGENIX DIM3X as long as they are committed to living a healthy lifestyle. Of course, it doesn’t hurt that it boasts some of the best ingredients needed for an effective estrogen blocker.


PrimeGENIX formulated DIM3X to provide maximum benefit to its users by selecting only the highest quality ingredients proven to stop the conversion of testosterone into estrogen.

The powerful ingredients that make the DIM3X formula outperform its competition are:

  • Diindolylmethane (DIM) – DIM has been shown to reduce estrogen levels as well as the adverse effects of estrogen in men. It has also been successful in blocking estrogen production in part because it helps regulate estrogen metabolism.
  • Bioperine (Black Pepper) – Bioperine is known for boosting the bioavailability of all other ingredients included in a supplement. This means that your body has a better chance of absorbing the nutrients and by extension the benefits, from other active ingredients.
  • AstraGin – This natural compound is a combination of Astragalus and Ginseng. Astragalus is often used to improve heart health and overall health while Ginseng has been linked to decreasing estrogen levels.
  • Vitamin E – This vitamin is a potent antioxidant and has anti-estrogenic properties, which means it helps reduce the negative effects of estrogen on men.


There are 120 capsules in each bottle of DIM3X, which is enough for a 30-day supply. The recommended dosage is four capsules taken daily with water.

Most users report experiencing noticeable results within four weeks of consistent use. No unwanted side effects have been reported when taken as directed.

Pros and Cons

The company behind PrimeGENIX DIM3X is Leading Edge Health (LEH), one of the top brands in the supplement industry. LEH is known for producing health supplements that include the highest quality of natural ingredients, as well as for its highly effective products.

The benefits of supplementing with DIM3X are numerous with hardly any drawbacks.


  • Inhibits estrogen production
  • Supports testosterone production
  • Increases fat metabolism
  • Boosts sex drive
  • Reduces the appearance of man boobs
  • Increases energy levels
  • Improves erectile function


  • Only available for purchase on the official website

Another amazing benefit of DIM3X is that it is manufactured in a cGMP facility in the USA. Production facilities with this certification have been stamped by the FDA as compliant with safe and transparent production methods. Supplements produced in these facilities contain optimal dosages of the listed ingredients and have been tested for quality, purity, and safety.

Where to Buy

DIM3X is only available through the official website for $59.95. Discounts are offered when you purchase three or six months at once. And free shipping within the USA is offered for orders over $200.

Whatever package you choose qualifies for a 100% satisfaction guarantee. You can take advantage of the 67-day risk-free trial and if for whatever reason it doesn’t work for you, you can send back the used and unused bottles for a full refund.

2) Nugenix Estro-Regulator

Nugenix estrogen blocker

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Nugenix Estro-Regulator is an estrogen blocker formulated to stop testosterone from converting into estrogen while simultaneously minimizing the harmful effects of having excess estrogen.


The key active ingredients in Nugenix Estro-Regulator include:

  • Diindolylmethane (DIM) – This naturally occurring plant compound helps boost metabolism, which helps you burn fat faster. It has also been shown to minimize the effects of high estrogen, allowing for hormonal balance.
  • Vitamin E – This vital antioxidant helps protect testosterone-producing cells and neutralizes free radicals. Some research has found it can help stimulate your body’s natural testosterone production.
  • Chrysin – This flavonoid found in plants has traditionally been used to treat erectile issues, as well as reduce anxiety and inflammation.
  • Polygonum Cuspidatum Extract (Knotweed) – Knotweed has been used to boost energy levels and stimulate libido by increasing blood circulation. This herb is also an excellent source of resveratrol, a polyphenol compound that supports heart health, brain function, and memory.

Nugenix is fully transparent with its ingredients and dosage amounts, unlike many other supplements that may hide behind proprietary formulas, meaning they tell you the ingredients, but hide the actual doses.


One bottle of Nugenix Estro-Regulator contains 60 pills, which is enough for one month. According to the label directions, you should take two capsules every morning with or without food.

Avoid the temptation to take more than the recommended amount. As long as you stick to the usage directions, this supplement is free of side effects.

Where to Buy

You can buy Nugenix Estro-Regulator on iHerb for $49.99 and can be found on other third-party retail sites.

It’s also available to purchase from the main Nugenix website for a few dollars more. Nugenix offers an 18-day risk-free trial period, which is short compared to other popular supplements.

3) Jacked Factory Androsurge

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Even though the name couldn’t be any more douchy, Androsurge by Jacked Factory is a solid natural estrogen blocker.

As with all the products on our list, Androsurge works by blocking the aromatase enzyme from converting testosterone to estrogen. But it goes a step further to increase blood flow and circulation, which helps you build muscle mass and harden your physique.


The following ingredients make up the Androsurge formula:

  • Diindolylmethane (DIM) – Found in most cruciferous vegetables, DIM helps facilitate the breakdown of estrogen into other metabolites. This makes it easier for your body to get rid of excess estrogen.
  • Grape Seed Extract – This extract is known for being a natural aromatase inhibitor in men with estrogen dominance.
  • Vitamin D3 – This vitamin encourages testosterone production to help keep it in balance with estrogen. It also helps boost energy levels and mood.
  • Rhodiola Rosea Root Extract – This extract contains salidroside, an active compound that helps suppress cortisol levels and boost natural testosterone production.
  • Bioperine – This premium black pepper fruit extract has been clinically shown to enhance the absorption and bioavailability of key nutrients.
  • Zinc – This vital mineral can positively improve male sexual health including healthy testosterone production.
  • Eurycoma Longifolia (Longjack) – Eurycoma has natural anti-estrogen properties and supports healthy testosterone levels.

The formula also helps naturally increase your free testosterone levels and androgen receptor sensitivity.


Each bottle of Jacked Factory Androsurge contains 60 pills, enough for a one-month supply. The recommended dosage of Androsurge is one (1) capsule taken twice a day for a total of two capsules per day. The manufacturer suggests taking your doses with a glass of water or 20 minutes before eating.

To achieve optimal results, it is recommended that you take Androsurge consistently for a cycle of 8-12 weeks. It can also be taken in conjunction with testosterone-boosting supplements.

These vegetarian-friendly capsules are produced in the USA in cGMP-certified facilities, so you can feel confident knowing Androsurge contains optimal doses of each quality ingredient listed on the label.

Where to Buy

Androsurge is available to purchase on their site for $39.99. It can also be found on the official Jacked Factory website for a similar price, as well as local health retail stores and several popular online shopping portals.

4) Force Factor DIM

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Force Factor DIM contains three solid ingredients for combating high estrogen levels. It also contains the highest dosage of DIM (300mg).

The Force Factor DIM formula includes the following:

  • Diindolylmethane (DIM) – This is a unique compound found naturally in cruciferous vegetables and has been used traditionally to lower estrogen levels in men. It may not directly increase your testosterone levels, but it supports testosterone’s effects on your body.
  • Bioperine (Black Pepper Fruit Extract) – This extract helps boost the bioavailability and absorption of the other two ingredients in the formula.
  • Selenium – This nutrient is essential for male sexual health as low levels of selenium have been linked to fertility issues in men. It also helps overall health by strengthening the immune system.

The combination of these three ingredients allows for quick absorption of each, and since they are all optimally dosed you can be confident that your high estrogen levels are a thing of the past.


Force Factor DIM comes in a bottle containing 30 capsules for one month of use. According to the directions on the bottle, one capsule should be taken daily with a meal. There is no indication of what time of day, so we assume the choice is up to the user.

Where to Buy

Force Factor DIM is the lowest-priced supplement on our list at $16.48. All Force Factor products are available for purchase from numerous other third-party sites and local retail stores. The company does not appear to sell directly through its official site, but you may find additional information about the products.

5) Pride Nutrition E-Block

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According to Pride Nutrition, E-Block is also useful for improving confidence and overall mood as a result of achieving your physical goals, but this is just marketing and a secondary consequence of the same effects as you’ll have with any of the supplements on our list.


E-Block is formulated with only three nutrients – Calcium D-Glucarate (650mg), Diindolylmethane (DIM) (250mg), and Chrysin (100mg). Together they help lower excess estrogen and rid your body of toxic chemicals.

While other estrogen blockers also work to eliminate toxins, without the inclusion of Calcium D-Glucarate estrogen may be reabsorbed before your gut can eliminate it. The inclusion of Calcium D-Glucarate helps prevent this reabsorption ensuring unwanted estrogen does not hang around.

Diindolylmethane (DIM) is one of the most important ingredients in any effective aromatase inhibitor. For a supplement to be truly effective it has to contain an optimal dosage of this ingredient. The company behind E-Block relied on scientific studies to ensure they included the right amount of DIM in the formula.

Chrysin is a compound found naturally in honeycomb and is the only ingredient that doesn’t add a lot of value to the formula. Chrysin is known to have a poor absorption rate, which is unfortunate since it was shown in lab settings to work as an excellent aromatase inhibitor.


A one-month supply of E-Block has 60 capsules, with a serving size of two capsules. The manufacturer recommends taking two capsules every day with your evening meal.

Post-cycle instructions listed on the bottle recommend taking two capsules with your morning meal and two capsules with your evening meal for 2-4 weeks. After which you should return to only taking one dose with dinner.

E-Block aromatase inhibitors are made in the USA using only the best, natural ingredients in safe and effective dosages.

Where to Buy

Pride Nutrition E-Block is available on their site for $59.99. They also offer discounts for military and first respondents, and for bulk orders. They also offer free returns.

How We Ranked

When we initially decided to compile a list of the best estrogen blocker supplements on the market, we first came up with a list of considerations.

The efficacy of any supplement comes down to the quality of ingredients, so naturally selecting products that contain some combination of the following ingredients was important. The presence of the following ingredients indicates a supplement is more likely to be effective:

  • Diindolylmethane (DIM)
  • Zinc
  • Vitamin D
  • Grape Seed Extract

Each of these ingredients is backed by research and known for its ability to aid in hormonal balance. Supplements that did not include any of these ingredients in their formulas (some had more than others) were excluded from our list. The products we did choose are therefore ranked by how strong the data is to support their effectiveness.

Aside from ingredients, other important factors we considered include where the supplement was manufactured (cGMP facilities only), the brand reputation, whether the product was free of adverse effects, and the cost-value ratio.

Our list is by no means exhaustive, which is why we wanted you to understand how we ranked the best estrogen blockers included here. This way you can make the best decision about which supplement is right for you.

About the Author

David William Rosales is a writer and strength coach. He's the head trainer and editor at Roman Fitness Systems. In addition to helping run RFS, he's also the head editor for, the official website of the Strength and Conditioning Association of Professional Hockey. You can also check out his Instagram, he's pretty easy on the eyes.

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