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6 Best Fisetin Supplements (2022) Reviewed and Compared

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For years, health experts have searched for ways to slow degenerative aging. Fisetin, a plant extract, might be a possible solution. Research suggests the benefits of fisetin might encourage healthy aging and even contribute to a longer lifespan. Today, we’re diving into those potential benefits and the best fisetin supplements on the market.

What is Fisetin?

Fisetin is a flavonoid found in some fruits like strawberries and apples. Compared to other flavonoids, fisetin has profound senolytic qualities, which are at the forefront of current anti-aging research. Based on these senolytic contents, fisetin might have the ability to slow the aging process. While more human studies are needed, what research we do have on fisetin is promising.

Why Should You Use A Fisetin Supplement?

Fisetin offers health benefits that might contribute to longevity.

Normally, old or dysfunctional cells die off so that new ones can take their place. As we age, however, some of these cells become senescent. This means that they fail to divide and perform as expected but also fail to die, pumping out toxins and inflaming the body.

Fisetin acts as a senolytic activator, which means it can kill senescent cells and make room for healthy ones. This is important because early research has suggested that cellular senescence might improve brain function. In one study, mice who received fisetin lived 2.5 months longer than average, even when treatment started late in their lifespan.

Other clinical trials suggest that fisetin can prevent aging in other ways too. One review suggests that fisetin can play a role in fighting disease by reducing age-inducing inflammation. Another study suggests that fisetin might induce the effects of a restrictive caloric diet which may help the body reduce inflammation and fight infection.

The Best 8 Fisetin Supplements

*Note: We do have affiliate links throughout this article, which means we receive a commission if you purchase from any of our links. This supports our mission to bring complicated health and fitness info in an entertaining package. And it keeps us from putting up annoying things like banner ads. Those suck.

1) Renue LIPO Fisetin – Powdered Liposomal Fisetin

Renue by Science LIPO Fisetin

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Renue LIP Fisetin is a potent supplement, containing 150 mg of fisetin in a liposomal capsule. Liposomes are a special lipid that surround active ingredients, like fisetin, so that they can survive the harsh environment of our digestion system, and therefore make it into the bloodstream. In a word, it enhances bioavailability. Renue LIPO Fisetin is suitable for vegans and contains 90 servings per bottle.

2) Fisetin LIPO Gel

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Are pills not your jam? Renue offers an alternative way to take fisetin with their Fisetin LIPO Gel. To use, just place two pumps under your tongue for fast absorption. Like the capsule, it’s vegan-friendly and contains liposomes. Each bottle contains 75 servings of 75 mg of fisetin.

3) Life Extension Bio-Fisetin

Life Extension Bio-Fisetin

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Life Extension Bio-Fisetin is both an affordable and effective option. It’s made with fibers derived from fenugreek seeds. These fibers might increase their bioavailability by preserving fisetin through the digestive process, keeping fisetin in the body for longer. It’s also gluten-free and vegetarian. Each bottle contains 30 vegetarian capsules, and each serving contains 45 mg of fisetin.

4) Double Tree Supplements Fisetin

Double Wood Supplements Fisetin

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Double Wood Supplements offers a potent and cost-effective option for your fisetin needs. Each bottle contains 60 servings, and each serving contains 100 mg of fisetin extracted from smoke tree stems. It’s vegan, gluten free, soy free, and manufactured in the USA.

5) Doctor’s Best Fisetin with Novusetin

Doctor's Best Fisetin with novusetin

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Each serving of Doctor’s Best contains Novusetin, which is a naturally sourced flavanol containing fisetin. It’s vegan, gluten free, and soy free. Each bottle contains 30 100 mg softgel capsules.

6) Purebulk Fisetin

PureBulk Fisetin

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PureBulk Fisetin gives you options. You can pick the kind (powder or capsule) and quantity of fisetin you want. Plus, both of the fisetin options are free of soy, dairy, gluten, and added sugars. If you prefer to buy in bulk, this one’s a great option.

How We Ranked

Although we ranked these supplements, we want you to decide on the best product for you. Here’s what we took into consideration when ranking these fisetin products.

Strict Testing Standards

The supplement industry isn’t FDA-regulated, which can make finding a reputable supplement challenging.

That’s why we only select companies that adhere to Good Manufacturing Practice (GMP) regulations and have their products third-party tested.

Ingredients

The average dose of fisetin given in clinical research has been around 100 mg, so we looked for products with similar doses. We also made sure the products we selected were free of any junk you don’t need, like additives and preservatives.

Value

You shouldn’t have to spend a fortune to live a healthy life. That’s why we selected high-quality products that won’t hurt your wallet.

Frequently Asked Questions

What Are the Side Effects of Fisetin?

As fisetin’s effectiveness as a supplement has only recently been explored, researchers have not yet determined its long-term effects. However, existing research indicates that fisetin is a safe supplement with no side effects, even in high doses.

What Is the Difference Between Fisetin and Quercetin?

Fisetin and Quercetin are both flavonoids. Like fisetin, quercetin has antioxidant and anti-inflammatory properties. It’s also believed to have a wide range of health benefits, from controlling blood sugar and reducing swelling to preventing heart disease and fighting against cancer. Yet, despite these benefits, fisetin has higher senolytic abilities than quercetin. This means fisetin might be a better choice when it comes to eliminating senescent cells.

Can Fisetin Be Taken if I Have Liver Disease?

Fisetin has no known side effects or medication interactions, so it might be okay to take if you have liver disease. In fact, animal studies suggest that fisetin might help treat ALD (alcoholic liver disease) by preventing oxidative stress. However, you should speak with a health professional before trying this supplement.

About the Author

Kelly is a Hawaii-based wellness writer. She graduated with her Master's degree in English and combines her background in health care, wellness, and fitness with her writing background to create content for various health-related companies. In her free time, you'll find her reading on the beach or training for her next half marathon.

Comments for This Entry

  • 12 Best Quercetin Supplements (2022) Reviewed and Compared

    […] Fisetin and Quercetin are both flavonoids. Like fisetin, quercetin has antioxidant and anti-inflammatory properties. It’s also believed to have a wide range of health benefits, from controlling blood sugar and reducing swelling to preventing heart disease and fighting against cancer. Yet, despite these benefits, fisetin has higher senolytic abilities than quercetin. This means fisetin might be a better choice when it comes to eliminating senescent cells. […]

    October 21, 2022 at 10:59 am

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