NMN supplements have become extremely popular the last few years as an anti-aging intervention.
The rise in popularity can largely be attributed to David Sinclair’s 2019 book, Lifespan, where he discusses NMN and the research from his lab at Harvard.
I’m usually skeptical of new products, and definitely skeptical when its popularity rides on the backs of one person and their bestselling book.
However, in the last few years, I’ve heard recommendations from other doctors I trust, like Dr. Peter Attia. And Sinclair has the respect of other great scientists in the public eye, like the prolific Andrew Huberman. Additionally, recent research continues to affirm its potential.
To me, then, I see NMN as an emerging intervention for anti-aging, and I’m looking much closer at the research. Clearly there’s something there, and the emerging questions over the next few years will be who it’s for, at what doses and frequency, what’s the best way to take it, and which NMN products stand out and why.
Okay, for starters, what is this molecule we’re talking about?
You can see this fancy-looking molecule right here. With its sexy-looking phosphate group (that phosphate has really been hitting the gym lately), and its ribose sugar to let you know it’s always up for a good time.
On a conceptual level, you may remember a molecule called NAD+ from high school biology and the dreaded Krebs Cycle. NMN is a precursor to NAD+. If you have more NMN, you’ll make more NAD+.
So to grossly oversimplify complex scientific processes, NMN plays a critical role in energy production. Remember that whole “the mitochondria is the powerhouse of the cell” thing. Well, that’s where NMN is working its magic. Inside the mitochondria.
Practically speaking, NMN has extensive research as an anti-aging molecule.
On a mechanistic level, NMN can improve our health and longevity by providing fuel for a class of proteins called “sirtuins.” Sirtuins are enzymes that help turn genes on and off as needed. They’re responsible for the “on and off” switch of tons of genes, including those that regulate things like aging, inflammation, detoxification, stress resistance, metabolism, circadian rhythms, and something called mitochondrial biogenesis. Their wide-ranging effects are partially what make sirtuins so interesting to study, because knowing how to activate them, which NMN can support, means we may be unlocking secrets to slowing aging, fighting inflammation, improving our metabolism, and more.
More specifically to longevity, these sirtuins can “turn on” longevity genes that keep us feeling young and spry. NMN can increase NAD levels, which increases sirtuin activity, which, researchers are discovering, is one of the key mechanisms for slowing down aging.
Think of sirtuins like Mike Wazowskis of the cell, always keeping the Sulleys on task. You can’t have a successful cell without them.
Sirtuins also increase during exercise and fasting, both of which have shown as key players in improving longevity.
Again, I’m oversimplifying complex processes here, so if you want to go into the nitty-gritty, I suggest first listening to some podcasts with Sinclair, or diving into the research yourself. Maybe at some point I’ll write something more substantial on it.
Today, we’re here to talk about action steps, and the best NMN supplements so you can take advantage of this purported fountain of youth.
Because there’s so much excitement and cutting-edge research in this space, there are also a ton of awesome companies developing one-of-a-kind, research-backed products.
*Note: We do have affiliate links throughout this article, which means we receive a commission if you purchase from any of our links. This supports our mission to bring complicated health and fitness info in an entertaining package. And it keeps us from putting up annoying things like banner ads. Those suck.
Best Overall: Wonderfeel® Youngr™ NMN
Best Sublingual: Renue by Science Citrus Sublingual Powder
Best Liposomal: Ultra Health PUR Liposomal NMN
Best Bulk: Renue by Science Micronized Powder
Youngr™ NMN provides a completely unique, trademarked formula developed by Harvard MD and leading biomedical scientist, Dr. Andrew Salzman. He has 30 years of direct research experience on NAD and NMN, and it shows in the quality of the product.
Simply, they have a patented form of NMN that no other companies have. Their patented NMN is more bioavailable, meaning it’s highly absorbable because it’s reinforced by a shield of enhancing agents, so it gets to your cell.
Typically, NMN goes through a complicated pathway to reach the cell. These enhancing agents help NMN to get through the bloodstream and into the cell where it needs to be and more importantly they protect the NMN inside the cell against the oxidants where it’s converted to NAD, which is the whole point.
Second, Youngr™ includes one of the highest doses, backed by the latest clinical trial. Each bottle contains 60 capsules with 450 mg of NMN in each capsule.
That’s much higher than other top products (usually around 150-250mg), for a similar price. Making overall a great value, even if the initial price, $73 with a subscription (and we recommend the subscription because the best impacts of NMN come when you take it consistently).
In addition to the high, clinically-tested dose of NMN, Youngr™…
All told, it’s no wonder Youngr™customers report remarkable results on everything from improving memory, to being able to run long distances again. It’s a fantastic formula with a high dose and competitive price.
You’ll see Renue by Science featured several times in this list, and that’s for a few reasons, which we discuss in the How We Ranked section of this article.
First, longevity is what they do. It’s their whole thing, and they’re damn good at it. All their products are not only third-party tested, but tested in an FDA-approved facility.
(This comes in contrast to most of the supplement industry, which is not FDA approved so companies can put almost whatever crap they want in their products and get away with it.)
Renue by Science’s powder works sublingually. This means you put the powder under your tongue and allow it to dissolve. The theory behind this is you can avoid the stomach altogether, which might increase the amount you actually absorb, although the jury is still out on this absorption comparison.
Additionally, they’ve added mannitol, which has also been shown to increase absorption (1).
It comes in a citrus-flavored powder which is quite delicious. Imagine a Fun Dip-esque experience, except it’s good for you.
All of this is why Renue by Science‘s Sublingual Powder is high up on our list at #2.
Ultra Health produces pharmaceutical-grade products, and they have the documentation to back it up. There’s little question about the quality. They manufacture their own products and without a doubt have the strictest quality standards on our list.
In 2022, they released a new version with a liposomal, enteric code to increase absorption.
The theory behind “liposomal” is that it surround the NMN in a protective layer, potentially helping increase bioavailability and absorption. This is a solid theory, but still a theory nonetheless, and liposomal capsules have basically no downside, other than the cost.
Even with the highest quality out there, Ultra Health NMN still competitively priced. Every bottle comes with 30 vegetarian capsules with 250mg of NMN for under $44.
This combination of unmatched quality, liposomal delivery, and competitive price is why Ultra Health NMN is our top liposomal pick.
Renue also has a liposomal capsule version.
Renue has the best cost per gram and among the strictest third-party testing.
For high-quality NMN in a bioavailable form, check out Renue LIPO NMN.
If you’re looking for a buy-in-bulk option, Renue by Science also carries NMN at just $1.45 per gram. That’s about four times the value of most other products. It’s not liposomal, but it’s not a capsule you swallow either. It’s sublingual. So you just put the powder under your tongue and allow it to dissolve. Early research shows this isn’t as bioavailable as liposomal options, but it’s better than just straight NMN that you swallow.
So while this is the most economical option, it’s the worst tasting one too. Now, it’s not terrible. It’s not as bad as unflavored leucine (that shit is terrible.) But it does have a bitter taste. Kind of like a weird-tasting lemon, is how I would describe it.
If you’re a wuss about things that taste bad, I’d go with either a capsule option or a flavored sublingual option.
If you pride yourself on stomaching unflavored supplements, then Renue’s Bulk Powder is the choice for you.
We have already talked about Ultra Health’s unmatched quality for their liposomal NMN product.
This product contains the same quality but with some additional ingredients. Each serving has 150mg of trans-resveratrol, which is also a promising ingredient in anti-aging research. You can read more about resveratrol in our guide on the best resveratrol supplements.
Codeage Liposomal NMN has a similar profile to Ultra Health’s Resversa-M liposomal. It has NMN and resveratrol, but it also has quercetin, which can help with heart health.
They also added B vitamins. One of the knocks on NMN is it can make you feel a bit fatigued, and b vitamins to keep your energy up.
This product is pricier than others, and resveratrol and quercetin are both powerful ingredients and not for everyone, so unless you want all of them, stick to another product.
Codeage is cGMP certified and third-party tested.
Renue also has a liposomal capsule version. As I said, a lot of the NMN in normal capsules succumbs to your stomach acid. In contrast, liposomal capsules are surrounded by a protective layer, so it makes it into your bloodstream.
Renue has the best cost per gram and among the strictest third-party testing.
This product also contains NMN, NR (another NAD precursor) and NAD itself. Each of these forms has slight differences. NAD+, for example, has been shown to cross the blood-brain barrier more effectively than NMN.
Meanwhile, NR, compared to NMN, seems particularly effective at elevating NAD+ levels in the liver.
This product combines all of the benefits, in a more bioavailable form.
Quicksilver scientific specializes in liposomal products. Unlike the previous two products, these don’t come in capsules, it comes in spray. This product also maintains strict third-party testing and a focus on high deliverability.
The knock on Quicksilver’s NMN is that it’s a much smaller dose per serving. Each serving has only 50mg of NMN, compared to Active and Codeage which have 250mg and 500mg per serving respectively.
Okay, this one isn’t an NMN product, it’s a direct NAD product. Now, there are differences here, but practically speaking, the benefits are similar. As mentioned, NAD seems to enter the blood-brain barrier more effectively.
This product avoids the stomach and mouth altogether. It’s probably the fastest way to your bloodstream. Let’s use our street smarts here and remember that this is why people usually snort drugs. It’s fast-acting.
The bottle also comes with a remarkable 120 servings for a reasonable price. Again, Active by Science is proving they’ll have the best prices on the market and remain among the highest quality. (Not to mention the innovative nasal spray.)
It doesn’t top our list because it’s not technically an NMN product, but if your goal is anti-aging, it should still be on your short list of considerations.
And if you know a direct NAD+ product is what you’re looking for, then you can check out our list of the best NAD+ supplements
Morphogen Nutrition’s MorphoVITA product is another all-in-one longevity supplement. Each serving contains 250mg of NMN along with Sibinol (a derivative of resveratrol) and a full gram of broccoli sprout powder.
All of this is packed into a third-party tested, competitively priced product. The knock on this product is the bioavailability of the NMN, because it’s not sublingual or liposomal.
If you’re looking for a comprehensive longevity product, MorphoVITA is a solid option. Also, Morphogen is a small company built on transparency and integrity, and I can personally attest to their quality.
ProHealth Longevity also has a lozenge option. Lozenge is a fancy term for a cough drop-like experience. It’s like a little candy. Per dose, this is about 4x more expensive than the sublingual powder they have, but compared to other companies, the price is still decent.
Double Wood Supplements is another quality company with third-party testing. Their NMN product has been around quite a while and they use organic ingredients in their product. It’s competitively priced, but not the best price around. And they don’t use a liposomal or sublingual delivery, so you’re going to lose out on a bit of bioavailability.
A bunch of factors went into the ranking system. In reality, the whole one-through-ten ranking system isn’t perfect, as some products might suit you better than others based on a number of factors. So here’s how we made our decisions, and you can use it to help you decide which product is best for you.
The supplement industry is filled with crap. Supplements are not regulated by the FDA, which means supplement companies get away with mislabeling their products, putting in banned and dangerous substances, and more.
For any supplement, that’s why it’s important to choose companies with third-party testing and GMP (good manufacturing practices) certification. Every product on our list fulfills this. For us it’s a prerequisite.
We gave companies a nudge if they take this to the next level. Companies like Wonderfeel, Renue by Science, and Ultra Health display their results transparently, and UltraHealth even uses pharmaceutical-grade ingredients.
This is especially important with NMN, because it’s a new product that has flooded the market. A recent third-party investigation found that 8 NMN brands were mislabeling their products. And many of these were bestsellers. That’s why we can’t emphasize enough the importance of a quality brand and a third-party tested product.
Straight NMN won’t all make it through your system into your cell. You’ll lose some to digestion. That’s why Wonderfeel’s Youngr™ has a patented formula to enhance delivery, and why other products use a liposomal option or sublingual option. Regular NMN products don’t make it high on our list.
If supplements taste bad, or if you have to mix them a ton, or if there are other roadblocks, then you’re less likely to take it. The experience needs to be able to fit into your routine. That’s why we bias good-tasting or capsule products over unflavored powders, even if they’re the best value.
The maxim goes that the best workout is the one that you do, and the same goes for NMN supplementation. If something, like a good-tasting product or a simple delivery system, will help you actually take it regularly, then do that.
Finally, we only selected products that weren’t outrageously priced for what you’re getting. We gave a nudge to those which are even better priced, like Renue’s bulk powder.
On a mechanistic level, the point of taking an NMN supplement is that it raises NAD levels. But what the heck does this do? Aside from writing it off as “longevity,” there are many more specific benefits for where raised NAD levels have shown promise.
Studies specifically on NMN supplementation have suggested that NMN via raised NAD levels may reduce age-related inflammation, improve insulin sensitivity (which often decreases with aging) improve mitochondrial function, improve neuronal function, and more.
Overall, this leads to effectively reduced biomarkers of aging.
And if you’re a mouse, as shown in this study, raised NAD levels may simply mean you’ll live longer.
This benefit is worth underscoring, because insulin is all about managing blood sugar, and “insulin resistance,” the opposite of insulin sensitivity, plays a fundamental role in type II diabetes. NMN supplementation may help with blood sugar management, and improve insulin sensitivity. For example, one study on prediabetic women showed exactly this.
A recent trial study on runners showed that those who took NMN performed better in aerobic activity. This is… wild. Up until now, the common thought around longevity science is that it often won’t improve performance, and may even reduce performance. But NMN might even improve athletic performance, and in the coming years it could enter the arena as a supplement for athletes.
The delivery system is one method to increase absorption. But it’s not the only way. While the research is super early and this is purely speculative right now, some have reported that anything high in a flavonoid called apigenin can improve absorption of NMN. Parsley, chamomile, celery, and artichokes are foods high in apigenin.
So grab a cup of chamomile tea or sprinkle some parsley on your dinner. I personally love using celery as a spoon for my peanut butter jar.
It’s unclear if this will help, but these are all healthy foods anyway, so at the worst you’ll just be… eating healthier.
Yes, you can. Broccoli, cabbage, mushrooms, and tomatoes mark a few foods that have high NMN. Raw honey also seems to help. Like all supplements, they’re meant to supplement. Eating a high-veggie, nutrient-dense diet will always be the foundation.
The truth is, if you want to live longer and have a higher quality of life, supplements won’t really do anything if you’re not exercising regularly (by doing something like one of our training programs), eating a nutritious diet with lots of vegetables, and getting high-quality sleep. That’s the best life-extension protocol out there.
NAD is at its highest in the morning and its lowest in the evening at the onset of sleep. In fact, NAD and one of the sirtuin genes it activates, SIRt1, help regulate our circadian rhythm. Generally, the best time to take NMN is in the morning.
Anecdotally, some people have used NMN while traveling to combat jet lag, with great success. While we need more research on this, I think using NMN to help regulate the circadian rhythm is low-risk, and based on what we know about the mechanisms, it makes a lot of sense.
Of course, we have to define “young” here. I’m thinking of people under, let’s say, 30. I haven’t seen any convincing research that it’s going to be effective for young people. And I think when we look at the mechanisms, there are diminishing returns.
NMN works because it restores NAD levels, but young people already have very high NAD levels. In theory they could go up even higher, or they could be tapped out. I haven’t seen any research one way or the other.
A more effective strategy would be to get your NAD tissue levels tested so you know your baseline. However, this is no a simple procedure, so getting NAD blood levels is cheaper and can give you a ballpark idea. Then you can see a drop off, and know when to start taking an NMN supplement. That’s what I’m personally doing (I’m 23), so I’ll let you all know in a few years.
For more on longevity-related products, you can check out our list of The Best Glutathione Supplements, which is a great supplement for overall health, and The Best Berberine Supplements, which targets another longevity mechanism, The AMPK proteins.