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9 Best Glutathione Supplements (2022) Reviewed and Compared

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Glutathione has been called “the mother of all antioxidants.” It’s a substance made from three amino acids: glycine, cysteine, and glutamic acid.

glutathione chemical structure

its glorious chemical structure

 

It’s involved in an array of bodily processes, from tissue repairs, to liver support, to skin rejuvenation.

glutathione skin health

There are tons of studies like this showing it helps you look and feel younger.

It supports in so many processes because it reduces oxidative stress (hence the whole “antioxidant” schtick), and supports many biomarkers for aging.

In sum, it makes you look healthier, feel younger, and perform better. It’s one of the leading substances in research with regards to longevity.

There are a lot of glutathione supplements out there, of various delivery mechanisms, doses, costs, and synergistic ingredients.

A lot of them are fantastic. Really, in researching this ingredient I’ve been pleasantly surprised by the quality out there right now. However, a lot of them aren’t so great, either.

We’re going to cover our top choices but we’ll also share how we made these decisions, so you can make the best choice for yourself, and know what to look for if you come across other products.

Without further ado, here are some of the best glutathione supplements on the market in 2022.

*Note: We do have affiliate links throughout this article, which means we receive a commission if you purchase from any of our links. This supports our mission to bring complicated health and fitness info in an entertaining package. And it keeps us from putting up annoying things like banner ads. Those suck.

Best Overall: Renue by Science LIPO Glutathione

1) Renue By Science LIPO Glutathione (Best Overall)

renue by science best glutathione supplement

 

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Renue by Science hosts an array of top-notch longevity and health products around, and their liposomal glutathione is no exception. You’ll note the “LIPO” prefix with their glutathione product.

That means it’s liposomal. One of the biggest problems with a lot of glutathione products is that they aren’t readily absorbed. In fact, the stomach acid breaks them down and renders them into simple amino acids again.

Liposomal glutathione is protected with a layer of lipids that the digestive tract can’t break down, substantially increasing the bioavailability. This has been demonstrated in a few studies in recent years (1) (2).

A few things separate Renue’s product from others. First off, they’ve gone above and beyond to not only have third-party testing, but their products are manufactured in an FDA-approved facility. Any Renue product will be exactly what you’re getting on the label.

They even publish the test results of each batch on their website. With every other company, we just can’t match that verification of purity and transparency.

Second, for such a high-quality product, it’s competitively priced with everything on the market. Each bottle comes with 90 servings of 130mg of liposomal-protected glutathione $50.

For the most effective, safe, and competitively priced product on the market, pick up Renue by Science’s LIPO Glutathione.

2) Double Wood S-Acetyl L-Glutathione

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While this product isn’t liposomal, some studies show forms of acetyl l-glutathione to be more bioavailable than regular glutathione.

One study even showed that acetyl l-glutathione was as effective as intravenous (IV) glutathione.

In general, if choosing between an acetyl l-glutathione or a regular, non-liposomal glutathione, I would go with the acetylated version.

This product comes with 60 capsules of 100mg each for less than $30. It’s high up on our list because of its high-quality from a trail-blazing brand in the longevity space, and because it’s a more affordable option to try out glutathione.

3) Seeking Health Optimal Glutathione Plus

seeking health best glutathione

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Seeking Health’s glutathione products are right behind Renue and Double Wood on our list. They’re also among the most reputable and transparent brands in the longevity supplementation landscape.

Their capsules are also liposomal.

There are a few differences in this product that may make it the best choice for you.

First, they include a form of N-acetyl l-glutathione. Some studies, although they’re limited, show that this acetylated form of glutathione has even better bioavailable, which is covered in this 2011 research review.

They also include several “cofactors,” which, Seeking Health argues, support the production of more glutathione in the body through the “glutathione recycling pathway.” These ingredients include riboflavin, selenium, molybdenum, and an antioxidant called Pyrroloquinoline Quinone (PQQ).

Riboflavin is a B vitamin and selenium molybdenum are minerals.

Reading through these biochemical explanations, I do believe Seeking Health is onto something here, but without more research, it’s hard to quantify this benefit. It stands to reason that if you get these vitamins and minerals through foods (but eating fruits and vegetables), then supplementing with them won’t be necessary.

Seeking Health’s product is quite a bit more expensive, with a $50 bottle coming with 60 servings and 100mg of glutathione. That’s fewer doses a smaller serving size for the same price.

That said, it’s also a top-tier product on the cutting edge of the longevity space. Learn more about Seeking Health Optimal Glutathione Plus.

4) Seeking Health Optimal Glutathione Plus – Liquid

seeking health liquid glutathione

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Seeking Health also has a liquid product, as opposed to capsules. It’s liposomal and contains all the co-factors that play a role in the glutathione recycling pathway. While it’s only 30 servings for $60, each contains 350mg of glutathione, so it’s competitively priced with Renue (still more expensive, but not by much), and cheaper than their capsules.

The downside is the liquid definitely isn’t as convenient. I personally tend to forget to take supplements when they’re in this spoon-fed liquid form.

5) Aurora Nutrascience Mega-Liposomal Glutathione (Best Value)

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This is also a liquid product, and it comes in liposomal form. In fact, all of Aurora’s products are liposomal. While they are GMP, third-party tested, they don’t go above and beyond with their purity testing like the previous companies.

That said, each serving comes with a whopping 750mg of glutathione per serving. With 32 servings for $50, you’ll get about twice the glutathione per dollar than other products, and just about another other product as well. And they have thousands of 5-star reviews from customers.

So if you’re looking to get the most bang for your buck, this is your best option.

6) Codeage Liposomal Glutathione

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Codeage also has a fantastic liposomal glutathione product. Each bottle has 60, 250mg capsules for under $40. And with our discount code, you can get it for even less.

They use a fermentation process called Setria ®️, and a phospholipid complex to aid in the deliverability.

7) Quicksilver Scientific Liposomal Glutathione

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Quicksilver Scientific argues that their liposomal products are absorbed better than other products because they use smaller particles, with an industry-leading, 100 nanometers (that’s really small) or less.

Logically, based on our knowledge of how absorption works this makes sense. The research on liposomal glutathione didn’t specify the size, and they don’t have specific studies to back up this higher absorption claim.

If I were to guess, it’s probably a bit more bioavailable, but not substantially so. For a similar cost, Quicksilver’s glutathione has smaller serving sizes, so you would be paying more, compared to the previous four recommendations.

That said, they’re a very reputable brand with strict testing.

This product also comes in a convenient spray form. So if that sounds like your vibe then go for it.

8) Toniiq Glutathione 98%

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The downsides to this product are the deliverability. Now we’re in the territory of ordinary glutathione products, which have suboptimal bioavailability.

However, each capsule of Toniiq’s product has a whopping 500mg of glutathione. Even if a lot of it succumbs to your stomach acid, you’ll still absorb a good dose. At just $32 for 60 capsules, it’s also a decent value.

Toniiq’s products aren’t only GMP-certified, they’re also made in an NSF-approved state-of-the-art manufacturing facility in the US. So in terms of purity, this is as good as any.

9) NOW Foods Glutathione

NOW Foods Glutathione supplement

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Like Toniiq, NOW Foods’ Glutathione product is simple but high-quality. NOW Foods has been around for decades, which speaks to the consistent simplicity and quality of their products.

They also have 500mg of glutathione per capsule.

I like that they have an option to buy just 30 capsules for less than $15. For the overall lowest cost to try glutathione, this is the best option on the market.

How We Ranked

While we’ve touched on it throughout, here’s what went into our thought process for ranking these products.

Delivery Mechanisms

Nearly all of our top picks have a liposomal delivery system. Regular glutathione has poor deliverability. Without any protection, most of it gets broken down by our stomach acid.

That’s why it’s common to take glycine, one of the amino acids in glutathione, instead of glutathione. However, with liposomal delivery, the glutathione makes it into your bloodstream.

There’s also some interesting, but limited research about acetyl l-glutathione and its bioavailability. However, because it’s limited, I’m unconvinced, and I’m more confident in the findings on liposomal delivery systems.

We included a few non-liposomal products on our list because they’re less expensive and higher dose, but we highly recommend going with a liposomal product, like Renue’s LIPO glutathione.

Company Quality

“Quality” means a variety of things here. We gave nudges to companies who specialize in these types of products.

Renue and Seeking Health are great examples of this. These types of longevity products are exactly what they do.

GMP and Third-Party Tested

Additionally, we looked for companies with strict, transparent testing processes. Being GMP, or “good manufacturing practices” certified is a prerequisite. The supplement industry has very little regulation, so companies can put things in products but keep them off the label.

We know that even with this, companies can seek their way around the testers, even if to marginal degrees.

If companies go beyond this and produce their products in FDA-approved facilities, or show the chemical results of literally every batch (as in the case of Renue), then we ranked them higher.

Cost

Obviously cost is a factor here. NOW Foods is a great place to start if you’re just looking to try glutathione. Renue ranks #1 because, although they’re not the cheapest, they compete with the best pricing per milligram considering the higher deliverability.

While I think Seeking Health’s and Quicksilver’s products are great, they are a bit pricier.

More on Longevity

Glutathione has shown a lot of promise in increasing our overall health. Another ingredient that more specifically targets longevity pathways is nicotinamide mononucleotide, or NMN.

For more on NMN, you can check out our list of The Best NMN Supplements.

There are plenty of other emerging longevity supplements too with other health benefits, which is the case with the super antioxidant quercetin. We also have a guide on The Best Quercetin Supplements.

And if your goal is specifically to improve your skin health or joint health, then you can read our guide on The Best Hyaluronic Acid Supplements.

FAQ

Frequently asked questions about glutathione and glutathione supplements.

Is Glutathione Effective When Taken Orally?

Glutathione on its own is not effectively absorbed by the body. That’s why our top choices all have delivery mechanisms that support absorption, like liposomal delivery. Liposomal capsules basically protect the glutathione molecules in lipid molecules so that they can make it through digestion and into the bloodstream.

How Much Glutathione Should I Take Per Day?

High doses of glutathione (above 500mg) tend to cause unwanted side effects like nausea and diarrhea. So 500mg a day is probably a good cap. However, that’s why it’s even more beneficial to choose products that focus on absorption instead of just dose. Renue’s LIPO glutathione only has 130mg, but the liposomal delivery mechanism improves deliverability, so you can more of the benefits without needing a high dose.

Are There Downsides to Taking Glutathione Long-Term?

Research dating back to 1998 suggests that frequent glutathione supplementation has been linked to lower zinc levels. So getting your blood work done to check your mineral levels is a good idea (and a good idea in general).

About the Author

David is a writer and strength coach and co-owner of Roman Fitness Systems. In addition to helping run RFS, he's also the head editor for prohockeystrength.com., the official website of the Strength and Conditioning Association of Professional Hockey. You can also check out his Instagram, he's pretty easy on the eyes.

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