12 Best Glutathione Supplements (2024) to Slow Aging, Support Immunity

Never miss a glorious update - click here!

✓ Medically Reviewed and Fact-Checked by Dr. Jesse Ropat, PharmD, RPh, B.Sc.

*AFFILIATE DISCLOSURE: We include links to products throughout this article. If you purchase through any of these links, we receive a commission

Glutathione, often hailed as the “the mother of all antioxidants,” is a vital component in the quest for optimal health and longevity

Composed of three amino acids – glutamine, glycine, and cysteine – it’s naturally produced in the liver and is present in every cell of the body

While its primary function is to protect cells from damage, it’s involved in an array of bodily processes, from tissue repair to liver function to skin rejuvenation

glutathione skin health

A wealth of research shows it helps you look and feel younger.

Overall, it reduces oxidative stress (hence the whole “antioxidant” schtick) and supports many biomarkers for aging. Antioxidants fight bad guys called “free radicals.” Glutathione stands as a formidable opponent against free radicals from environmental pollutants, processed food, alcohol, smoking, pharmaceuticals, and chronic stress. It’s like… the obi-wan of fighting free radicals.

In sum, it makes you look healthier, feel younger, and perform better. 

It’s one of the leading substances in longevity research, and it’s only getting more popular and widely used. So, let’s get into the best glutathione supplements in 2023. We’ll also share how we made these decisions, so you know what to look for when choosing a product (hint: liposomal glutathione).

Oh look, a neat little table of contents.

What are the Best Liposomal Glutathione Supplements in 2024?

There are a lot of glutathione supplements out there with various delivery mechanisms, doses, and synergistic ingredients. I’ve been pleasantly surprised by the quality out there right now. However, a lot of them aren’t so great, either.

Without further ado, here are the best glutathione supplements on the market in 2024:

*AFFILIATE DISCLOSURE: We have affiliate links throughout this article. This means we receive a commission if you purchase from any of our links. This supports our mission to bring complicated health and fitness info in an entertaining package. And it keeps us from putting up annoying things like banner ads. Those suck.

Best Liposomal Glutathione Supplement: Renue by Science LIPO Glutathione

Best Glutathione Liquid Supplement: Seeking Health Liposomal Glutathione Plus

Best Liposomal Glutathione Sachets: LivOn Labs Lypo-Spheric Glutathione

Best Glutathione for Immune Health: Performance Lab PL-Immune™

Best Acetyl L-Glutathione Supplement: Double Wood S-Acetyl L-Glutathione

Best Value Glutathione Supplement: Aurora Nutrascience Mega-Liposomal Glutathione

Best Glutathione Supplement with Alpha Lipoic Acid: NOW Foods Glutathione

Best Glutathione for Liver Support: Doctor’s Best L-Glutathione with Milk Thistle

1) Renue By Science LIPO Glutathione (Best Overall)

renue by science best glutathione supplement

Check Lowest Price And Use Code “RFS10” For 10% Off 


(Disclosure: This is an affiliate link)


  • 130 mg of liposomal glutathione
  • Third-party tested
  • Manufactured in an FDA-approved facility in the USA
  • Best bioavailability
  • 10% off with our link


  • None

Renue by Science stands out in the health and longevity product market, particularly with its glutathione offering. You’ll note the “LIPO” prefix with their glutathione product.

That means it’s liposomal. This is crucial because standard glutathione supplements often suffer from poor absorption, breaking into simple amino acids due to stomach acid and digestive enzymes.

So, what is liposomal glutathione?

Liposomal glutathione is encased in a lipid layer that resists breakdown in the digestive tract, significantly enhancing bioavailability, as evidenced by several studies.

Liposomal glutathione is protected with a layer of lipids that the digestive tract can’t break down, substantially increasing the bioavailability. This is backed by a few studies in recent years (1) (2).

Basically, if you don’t get a product like Renue’s that focuses on deliverability, you’re wasting your money.

And with our link, you can get 10% off all Renue products.

Beyond that, a few things separate this product.

They’ve gone above and beyond to not only have third-party testing but also manufacture in an FDA-approved facility in the USA. They even publish the test results of each batch on their website.

With other companies, we can’t match that verification of purity and transparency.

LIPO Glutathione is non-GMO, suitable for vegans, gluten-free, and contains zero artificial colors, flavors, or preservatives. They come in convenient glutathione capsules.

For such a high-quality product, it’s competitively priced with others on the market. Each bottle contains 90 servings of 130 mg of liposomal-protected glutathione, with 10% savings available with our link. Given its effectiveness, safety, and competitive pricing, Renue by Science LIPO Glutathione

2) Performance Lab PL-Immune™ (Best Glutathione for Immune Health)

Check Lowest Price

(Disclosure: This is an affiliate link)


  • 250 mg Setria® glutathione
  • Includes zinc, vitamin D, selenium, IMMUSE probiotic, and vitamin C
  • High-quality, patented forms of nutrients
  • Best for immune support


  • More expensive
  • Not liposomal

Performance Lab PL-Immune™ is another standout product featuring Setria® glutathione. Each capsule delivers a substantial 250 mg dose of pure glutathione.

This is a high dose per capsule. What makes PL-Immune™ stand out, though, are the synergistic ingredients to support your immune system and performance. This includes zinc, vitamin D, selenium, IMMUSE probiotic, and vitamin C. Essentially, it’s packed with ingredients to support your immune function.

They only use high-quality, patented forms of every ingredient on the label.

The high-quality, patented ingredients make PL-Immune™ a strong contender for the top spot. PL-Immune™ is vegan-friendly, gluten-free, non-GMO, cGMP-certified, and comes in convenient capsules.

For these reasons, Performance Lab PL-Immune™ is our #2 pick. 

3) Double Wood S-Acetyl L-Glutathione (Best Acetyl L-Glutathione)

best liposomal glutathione supplement

Check Lowest Price

(Disclosure: This is an affiliate link)


  • 100 mg of S-Acetyl L-Glutathione
  • Capsule-based
  • Affordable option
  • Trusted, family-run brand


  • Not liposomal delivery

Double Wood S-Acetyl L-Glutathione, although not liposomal, has shown promise in studies for its bioavailability, rivaling even intravenous glutathione. This study shows it’s as effective as intravenous (IV) glutathione.

For those deciding between acetyl l-glutathione and non-liposomal glutathione, the acetylated version is better.

This product comes with 60 capsules of 100 mg. It’s high up on our list because of its high quality from a quality brand and because it’s a more affordable option to try out glutathione.

4) Seeking Health Liposomal Glutathione Plus (Best Liquid Glutathione)

Optimal Liposomal Glutathione

Check Lowest Price

(Disclosure: This is an affiliate link)


  • Lipsomal Form
  • Contains several co-factors that support the “glutathione recycling pathway”
  • Liquid


  • More expensive

Seeking Health has a great liposomal glutathione that comes in liquid. It contains all the co-factors that play a role in the glutathione recycling pathway.

While it’s only 30 servings for $60, each contains 350mg of glutathione, so it’s competitively priced with Renue (still more expensive, but not by much), and cheaper than their capsules.

I personally tend to forget to take supplements when they’re in this liquid form, but if you prefer liquid, this is a great option.

5) Seeking Health Optimal Glutathione Plus

seeking health best glutathione

Check Lowest Price


(Disclosure: This is an affiliate link)


  • 100 mg of liposomal N-acetyl l-glutathione
  • Contains several co-factors that support the “glutathione recycling pathway”
  • 60 servings


  • More expensive
  • Not ideal if you’re only looking for glutathione

Seeking Health’s glutathione products are among the most reputable and transparent brands in the longevity supplementation landscape.

Their glutathione capsules are also liposomal, and they include a form of N-acetyl l-glutathione. Some studies, although limited, show that this acetylated form of glutathione has even better bioavailability. It’s covered here in this 2011 research review.

They also include several “cofactors,” which, Seeking Health argues, support the “glutathione recycling pathway.” These ingredients include riboflavin, selenium, molybdenum, and an antioxidant called Pyrroloquinoline Quinone (PQQ).

Riboflavin is a B vitamin, and selenium and molybdenum are minerals.

Reading through these biochemical explanations, I believe Seeking Health is onto something here, but without more research, it’s hard to quantify this benefit. It stands to reason that if you get these vitamins and minerals through foods, then supplementing isn’t necessary.

Seeking Health’s product is quite a bit more expensive than others on the list, with a bottle containing 60 servings and 100 mg of glutathione.

That said, it’s also a top-tier product on the cutting edge of the longevity space. Learn more about Seeking Health Optimal Glutathione Plus.

6) LivOn Labs Glutathione (Best Liposomal Glutathione Sachets)

Glutathione Carton


Check Lowest Price

(Disclosure: This is an affiliate link)


  • Liposomal delivery
  • 300 mg Setria® Glutathione
  • Convenient sachets


  • Sachets create more waste

LivOn Labs Lypo-Spheric Glutathione uses liposomal technology, ensuring enhanced absorption and effectiveness.

It contains Setria® Glutathione, a clinically proven form of glutathione that may raise blood glutathione levels by 30%. Plus, it uses liposomes, tiny vesicles that protect the glutathione from breakdown in the digestive system.

It comes in single-dose packets to ensure freshness and effectiveness, with each packet containing 300 mg of liposomal glutathione.

LivOn Labs products are manufactured using state-of-the-art technology and undergo rigorous testing to ensure purity and potency.

The Lypo-Spheric Glutathione stands out as a superior choice for those seeking the benefits of glutathione in a highly absorbable form.

7) Aurora Nutrascience Mega-Liposomal Glutathione (Best Value)

Check Lowest Price

(Disclosure: This is an affiliate link)

This is also a liquid product, and it comes in liposomal form. In fact, all of Aurora’s products are liposomal. While they are GMP, third-party tested, they don’t go above and beyond with their purity testing like the previous companies.

That said, each serving comes with a whopping 750 mg of glutathione per serving. With 32 servings for $50, you’ll get about twice the glutathione per dollar than other products, and just about another other product as well. And they have thousands of 5-star reviews from customers.

So if you’re looking to get the most bang for your buck, this is your best option.

8) Codeage Liposomal Glutathione

Check Lowest Price and Use Code “ROMAN10” for 10% off

(Disclosure: This is an affiliate link)

Codeage Liposomal Glutathione features 500 mg of Setria® L-Glutathione, a patented form of glutathione that uses a fermentation process and a phospholipid complex to aid bioavailability.

The supplement uses vegetable capsules and contains no gluten, dairy, soy, or GMOs. Additionally, it is keto-friendly and does not contain shellfish.

Manufactured in the USA in a cGMP-certified facility, this product undergoes rigorous third-party testing to ensure its quality and efficacy. With a focus on sustainability, Codeage is committed to environmental responsibility, further enhancing the appeal.

With our discount code, you can get it for a great deal.

9) Quicksilver Scientific Liposomal Glutathione

Liposomal Glutathione bottle

Check Lowest Price

(Disclosure: This is an affiliate link)

Quicksilver Scientific is a liquid product with 100 mg of glutathione per serving in 75 mg of phosphatidylcholine from purified sunflower seed lecithin. 

QS argues that their liposomal products are absorbed better than others because they use smaller particles. They use an industry-leading, 100 nanometers (that’s really small) or less.

Logically, based on our knowledge of how absorption works, this makes sense. But there aren’t specific studies to back up this higher absorption claim. If I were to guess, it’s probably a bit more bioavailable, but not substantially so

Quicksilver’s glutathione has smaller serving sizes, so you’re paying more than the previous four recommendations.

That said, they’re a reputable brand with strict testing.

This product also comes in a convenient spray form. So, if that sounds like your vibe, then go for it.

They recommend taking 2 pumps of the supplement, holding it in the mouth for 30 seconds before swallowing, and taking it on an empty stomach for optimal absorption.

10) Toniiq Glutathione 98%

Check Lowest Price

(Disclosure: This is an affiliate link)

Now we’re in the territory of ordinary glutathione products, which have suboptimal bioavailability. Toniiq Glutathione is a great product, but the downside is the deliverability.

However, each capsule has a whopping 500 mg of glutathione with 98%+ purity. This high concentration ensures more active compounds are available. Even if a lot of it succumbs to your stomach acid, you’ll still absorb a good dose. 

Toniiq’s products aren’t only GMP-certified, they’re also made in an NSF-approved state-of-the-art manufacturing facility in the US. 

As part of Toniiq’s 5 Point Testing Program, they include checks for microbiology, heavy metals, and assay of active ingredients in both raw materials and the finished product.

In terms of purity, this is as good as any.

11) Doctor’s Best L-Glutathione with Milk Thistle (Best Glutathione for Liver Support)

best liposomal glutathione supplement

Check Lowest Price

(Disclosure: This is an affiliate link)

Doctor’s Best is renowned for its commitment to science-based nutrition and has a reputation for producing high-quality supplements.

Their Glutathione + Milk Thistle supplement combines the powerful antioxidant properties of Setria® Glutathione with the benefits of Milk Thistle extract. This unique blend supports liver health and boosts antioxidant activity.

Doctor’s Best is committed to non-GMO, gluten-free, and soy-free products, ensuring high-quality and safety standards.

12) NOW Foods Glutathione (Best Glutathione with Alpha Lipoic Acid)

NOW Foods Glutathione supplement

Check Lowest Price

(Disclosure: This is an affiliate link)

NOW Foods presents its glutathione supplement as a potent 500 mg dosage in each vegetarian capsule.

NOW Foods has been around for decades, which speaks to the consistent simplicity and quality.

This glutathione product also includes milk thistle extract for detox and liver health. Finally, it includes alpha lipoic acid, another antioxidant. 

The supplement is non-GMO, vegetarian, vegan, and kosher, adhering to high-quality standards.

For the overall lowest cost to try glutathione, this is the best option on the market.

How We Ranked the Best Glutathione Supplements

While we’ve touched on it throughout, this is how we ranked these products.

Purity and Potency

We prioritized supplements with effective levels of active glutathione. Products with higher purity and potency were ranked higher.

Delivery Mechanisms

Many of our top picks have a liposomal delivery system. Regular oral glutathione has poor deliverability. Without any protection, most of it gets broken down by our stomach acid.

That’s why it’s common to take glycine, one of the amino acids in glutathione, instead of glutathione. However, with liposomal delivery, the glutathione makes it into your bloodstream.

There’s also some limited research about acetyl l-glutathione and its bioavailability. However, I’m more confident about liposomal delivery systems.

We included a few non-liposomal products on our list because they’re less expensive, but we highly recommend going with a liposomal product, like Renue’s LIPO glutathione.

Company Quality

“Quality” means a variety of things here. We gave nudges to companies that specialize in these types of products.

Renue and Seeking Health are great examples of this. These types of longevity products are their “thing.”

GMP and Third-Party Tested

We look for companies with strict, transparent testing processes. Being GMP, or good manufacturing practices certified, is a prerequisite. The supplement industry has very little regulation, so companies can put things in products but keep them off the label. Every product on our list passes the GMP certification.

We know that even with this, companies can seek their way around the testers, even if to marginal degrees.

If companies go beyond this and produce their products in FDA-approved facilities or show the chemical results of literally every batch (as in the case with Renue), then we rank them higher.

Plus, supplements that have undergone rigorous third-party testing for safety and quality scored higher in our rankings.

Ingredient Quality

If you look at a product like PL-Immune™, you’ll notice they use patented forms of every ingredient. While patented doesn’t necessarily mean better, it demonstrates a standardized process for getting ingredients. This often means lower heavy metal amounts and purer products.

We favored products made with high-quality, non-GMO, and allergen-free ingredients.


Obviously, cost is a factor. NOW Foods is a great place to start if you want to try glutathione. Renue ranks #1 because, although they’re not the cheapest, they compete with the best pricing per milligram, considering the higher bioavailability.

While Seeking Health’s and Quicksilver’s products are great, they are pricier.

What is Glutathione?

Glutathione is the “master antioxidant,” produced in the body. Overall, it’s crucial to defend your cells against oxidative stress.

To get a bit nerdy, oxidative stress occurs when there’s an imbalance between reactive oxygen species (the bad guys) and the antioxidants that quench them.

If the imbalance becomes too great, it can cause cellular and DNA damage, cardiovascular disease, and inflammation, among other health impacts.

Reactive oxygen species (free radicals) aren’t always bad, but glutathione keeps your antioxidant balance in check.

That said, glutathione levels are depleted by aging, poor nutrition, stress, lack of sleep, and environmental pollutants.

To boost glutathione levels, incorporate certain foods into your diet, like cruciferous vegetables, garlic, onions, asparagus, avocado, spinach, kale, eggs, Brazil nuts, meat, fish, and whey protein. Regular exercise, effective stress management, and quality sleep also contribute to optimal glutathione levels. However, research points toward supplements as another helpful way to stay on top of glutathione stores.

The Health Benefits of Glutathione Supplementation

Since glutathione is an antioxidant, its health benefits are extensive. It fights free radical damage, acting as a powerful scavenger against oxidative stress and helping to recycle other antioxidants like vitamins A, C, E, and alpha-lipoic acid. 

As an anti-aging compound, glutathione minimizes cell damage and death, protecting vital organs and reducing signs of aging such as muscle wasting, weak bones, wrinkles, and sagging skin. It also preserves mitochondrial function for energy production and metabolism.

In detoxification, glutathione is essential for the liver’s phase two detoxification process, helping to neutralize and excrete toxins like drugs, heavy metals, and pesticides. This process is key to feeling energetic and healthy.

As a supplement, its strongest benefit is to improve immune health and function.

It also has decent evidence to support liver function. One study on non-alcoholic fatty liver disease showed an improvement with 300 mg of oral glutathione for four months.

Glutathione has many other potential benefits. For example, some research talks about the role of low glutathione in those with psoriasis.

Other research showed cognitive improvement in those with Alzheimer’s. However, this does NOT make glutathione a viable treatment for these diseases. Rather, it’s another piece of evidence pointing to glutathione’s role in health.

The bottom line is that glutathione is a powerful antioxidant with a host of downstream benefits.

best liposomal glutathione supplement

Some of the things this little gem does — via VeryWellHealth

Why Liposomal Glutathione Should Be Your First Choice

If your budget allows, liposomal glutathione stands out as a particularly effective form of glutathione supplementation, offering advantages over regular glutathione.

Regular glutathione supplements often face challenges in terms of absorption and bioavailability. It breaks down in the digestive tract before reaching the bloodstream, reducing its effectiveness. Liposomal glutathione, however, is encapsulated in liposomes – tiny, spherical vesicles made from naturally occurring phospholipids. This liposomal encapsulation protects glutathione from being degraded in the digestive system, ensuring more of it is taken into the bloodstream.

Liposomes are also structurally similar to cell membranes, which allows them to merge with the membranes of cells in the body more easily. This facilitates the direct delivery of glutathione into the cells.

Furthermore, glutathione in its regular form is prone to degradation when exposed to environmental factors like air and light. The liposomal form has better shelf stability, ensuring the supplement retains its potency over time.

Finally, regular glutathione supplements can cause digestive issues in some people. The liposomal form is easier to absorb, reducing the likelihood of gastrointestinal distress.

Overall, liposomal glutathione has enhanced absorption and bioavailability, which are crucial for maximizing the benefits. This is why we put liposomal options at the top of our list.


Here are the answers to the most frequently asked questions about glutathione supplements.

Does Glutathione Support Exercise Performance?

Glutathione supplements may support exercise performance. This study showed that glutathione could reduce fatigue and lower lactic acid levels in the blood after eccentric exercise, reducing the risk of muscle soreness over 72 hours.

That said, glutathione isn’t a general fitness supplement. If you want something to support gains, check out our articles on creatine and BCAAs.

Is Glutathione Effective When Taken Orally?

Glutathione on its own is not particularly effective. That’s why our top choices all have delivery mechanisms that support absorption, like liposomal delivery.

Liposomal capsules protect the glutathione molecules in lipid molecules so they can make it through digestion and into the bloodstream.

How Much Glutathione Should I Take Per Day?

Taking high doses of glutathione, exceeding 500 mg, may lead to side effects such as nausea and diarrhea. 

However, choosing products that prioritize absorption rather than just dosage is beneficial. For instance, Renue’s LIPO glutathione only has 130 mg, but the liposomal delivery mechanism improves deliverability, so you can get the benefits without needing a high dose.

What Time of Day Should I Take Glutathione Supplements?

Because of its suboptimal bioavailability, you should take it first thing in the morning on an empty stomach.

Is Liposomal Glutathione Really More Effective?

The early research on liposomal glutathione vs. regular glutathione seems promising.

There are a few recent studies on humans that show liposomes raise glutathione levels in the blood. 

Can I Absorb Glutathione Transdermally (through the skin) In a Cream or Spray?

Because of its impact on longevity and questionable oral bioavailability, glutathione is a popular ingredient in many “anti-aging” creams. That raises the question of whether we can absorb glutathione through our skin. 

The answer seems to be maybe. That is, we don’t know yet. And even in the case of transdermal delivery, liposomal options seem to be the most effective. 

If you want to go that route, we recommend checking out this face serum product from Renue that contains NAD+, glutathione, collagen, and more, making it a total anti-aging cream.


renue by science anti-aging face serum

Check Lowest Price And Get 10% Off

For more on anti-aging creams, we touch on the topic in our article on the best NAD+ supplements.

What About Intravenous Glutathione Therapy?

This is a big topic, so we have a whole article on the benefits of IV glutathione to help you decide whether this trend is worth your time.

What is the Difference Between Liposomal Glutathione vs Reduced Glutathione?

The difference between reduced glutathione and liposomal glutathione lies in how they are absorbed and used by your body.

Reduced L-glutathione, or GSH, is the active form of glutathione that functions as an antioxidant in the body. It is a tripeptide composed of glutamine, cysteine, and glycine.

That said, supplementing reduced glutathione on its own may break down before it reaches the bloodstream.

Liposomal glutathione is reduced glutathione encapsulated within liposomes that are similar to cell membranes. This protects glutathione from being degraded by stomach acids and enzymes.

Can Glutathione Supplements Help with Skin Whitening?

Glutathione is often marketed for its skin-whitening effects, but the scientific evidence supporting this is limited.

The primary role of glutathione in the body is as a powerful antioxidant, and its impact on skin tone may be a secondary effect.

The mechanism behind its potential skin-lightening ability may be its influence on melanin production in the skin. However, we don’t suggest it.

Can Glutathione Supplements Interact with Other Medications?

Glutathione supplements have few known severe interactions with other drugs. However, as with any supplement, there can be potential interactions, especially with chemotherapeutic agents. It’s crucial to consult with a healthcare provider before starting glutathione supplements.

Are There Downsides or Side Effects to Taking Glutathione?

Research dating back to 1998 suggests frequent glutathione supplementation may lower zinc levels. So, monitoring mineral levels through blood work is advisable (and a good idea in general).

Plus, higher doses can cause bloating and general stomach distress. If you know you have a sensitive stomach, start with a smaller dose.

Can I Get Glutathione from Food?

Not in the concentrated dose found in supplements. But the body uses precursors like sulfur and cysteine — from garlic, onions, cruciferous vegetables, eggs, and seafood – to produce glutathione in the body.

Can I Take NAC instead of Glutathione?

NAC (N-Acetyl Cysteine) is a derivative of the amino acid cysteine — and a precursor to glutathione. It has its own benefits, which may or may not be linked to glutathione production. 

Interestingly, these supplements work well together. However, one may suit you better. For more detail, we wrote an entire article to help you decide between NAC and glutathione.

What Other Supplements Support Your Immune Health?

Most of us should be supplementing with vitamin D, and you can learn more about the best options in this article on the best vitamin D3 and K2 supplements.

More on Longevity

Glutathione has shown a lot of promise in increasing our overall health. Another ingredient that targets longevity pathways is nicotinamide mononucleotide or NMN. For more on NMN, you can check out our list of The Best NMN Supplements.

There are plenty of other emerging longevity supplements with other health benefits, which is the case with the super antioxidant quercetin. We also have a guide on The Best Quercetin Supplements.

Finally, if your goal is to improve your skin or joint health, read our guide on The Best Hyaluronic Acid Supplements.

About the Author

David William Rosales is a writer and strength coach. He's the head trainer and editor at Roman Fitness Systems. In addition to helping run RFS, he's also the head editor for, the official website of the Strength and Conditioning Association of Professional Hockey. You can also check out his Instagram, he's pretty easy on the eyes.

Comments for This Entry

Leave a Comment