This one goes out to all the hayfever sufferers
✓ Medically Reviewed and Fact-Checked by Dr. Jesse Ropat, PharmD, RPh, B.Sc.
No, it’s not a slur. Quercetin – pronounced qwer-se-tin – is a brilliant, yellow-colored polyphenol (a fancy antioxidant) especially abundant in blueberries, capers, onions, apples, and more. In fact, here’s a nice little chart from this study on quercetin.
Common descriptors for quercetin include antioxidant and anti-inflammatory, which make it sound super healthy. It fights free radicals, which are the bad guys.
It’s no wonder it’s become one of the most popular health supplements for health and longevity. Even some of our favorite podcasters and neuroscientists, like Dr. Huberman, include it in their daily supplement regimen.
Today we’re looking at the best quercetin supplements on the market. We’ll also answer your FAQs about this fascinating flavonoid.
One of the main issues with quercetin supplements is low oral bioavailability. If a product doesn’t plan accordingly to support bioavailability, then it won’t be as effective.
With that in mind, here are the best quercetin supplements on the market:
Best Liposomal Quercetin Supplement: Renue by Science LIPO Quercetin
Best Quercetin Phytosome Supplement: Thorne Quercetin Phytosome
Best Quercetin and Resveratrol Supplement: Thorne ResveraCel
Best Quercetin and Bromelain Supplement: Thorne Quercenase
Best Quercetin for Allergies: Quicksilver Scientific Hista-Aid
Best Quercetin Supplement for Anti-Aging: Renue by Science NAD+ ACTIVATOR
Best Bulk Quercetin Supplement: Pure Bulk Quercetin
*Note: We do have affiliate links throughout this article, which means we receive a commission if you purchase from any of our links. This supports our mission to bring complicated health and fitness info in an entertaining package. And it keeps us from putting up annoying things like banner ads. Those suck.
Renue LIPO Quercetin is our top pick because it uses liposomal capsules that protect the quercetin during digestion and increase bioavailability. As we mentioned, if a supplement gets destroyed in the stomach, you won’t get any effects.
A June 2021 study found a 20-fold increase in absorption when using liposomal quercetin compared to ordinary quercetin.
Read that again. A 20-time increase.
You actually absorb Renue LIPO Quercetin.
Second, Renue has some of the strictest and cleanest testing policies. Every batch is GMP-certified AND made in an FDA-approved facility.
Every batch is third-party tested, and the purity results are available online for all to see.
Each bottle contains 90, 150 mg capsules. The dose is lower than some products. But remember, it has better absorption. You get more quercetin despite a lower dose.
For reasons, Renue LIPO Quercetin is our #1 pick.
If you really want to cook with some metaphorical longevity spice, this supplement might spark your interest.
It’s more than just quercetin, it’s a complete longevity recipe.
Your body more readily absorbs this supplement with its liposomal delivery system. It allows this cocktail of senolytic and AMPK activator compounds to help your body eliminate sensate cells that have stopped multiplying but refuse to die off.
It also helps preserve and maintain your NAD+ stores – for cellular processes and slowing aging.
Additionally, spermidine may extend the lifespan of mice, and as the evidence continues to grow, we believe it may carry over into humans as well.
We think it’s the best combination product on the market, making this the second-best quercetin supplement available (or #1 if you want more than a single-ingredient longevity supplement).
PartiQlar quercetin stands out because it uses Pure quercetin at a high dose and a fair price. It’s a simple formula with nothing but quercetin, allowing them to bring it at an affordable price.
Another great benefit of this product is it’s made in the USA and comes with a 60-day money back guarantee. So if it doesn’t work for you, there’s no risk.
This product from Thorne derives its strength from a combination of quercetin and resveratrol. Each capsule contains 125 mg of quercetin and 75 mg of resveratrol.
Research on quercetin shows it has a synergistic effect when combined with resveratrol, as per this 2015 study. This means that when taken together, it boosts both their positive effects. Plus, resveratrol has a lot of research for anti-aging, longevity, and overall health.
It also contains over 200 mg of NR (nicotinamide ribose), a precursor to NAD. We’ve talked about this in-depth in our article on another NAD precursor, NMN.
Thorne is also a third party-tested, cGMP-approved company with a great reputation.
On the downside, Thorne’s product isn’t liposomal. While the cocktail of anti-aging ingredients is impressive, we have concerns about the bioavailability and absorption.
Thorne Research Quercetin Phytosome is another unique formula. Each capsule delivers 250 mg quercetin in a phytosome complex.
Phytosomes, like liposomes, are lipids. They’re different kinds of lipids but have the same idea with the goal of improving the bioavailability for optimal absorption.
This phytosome complex easily crosses the gut barrier, making it more bioavailable than non-phytosome forms of quercetin.
A 2019 study found the bioavailability of quercetin phytosome was higher than regular quercetin dihydrate (the typical form).
Again, Thorne only makes high-quality products, so this makes our shortlist.
In terms of a combination of value, quality, and a high dose, Double Wood’s quercetin product contains 600 mg per capsule. It also provides 100 mg of bromelain, another anti-inflammatory enzyme from pineapples.
Quercetin supplements often include bromelain because research suggests the anti-inflammatory benefits are synergistic, meaning that they work best in combination. Bromelain may also improve the bioavailability of quercetin.
Double Wood goes beyond the GMP certification. They display their certificate of analysis for purity on their website.
This product is also phenomenal value and comes in a bottle of 120 capsules. Plus, it’s soy-free, gluten-free, non-GMO, and vegan.
If you want a quality, inexpensive, simple product, NOW Foods quercetin is for you. Each capsule contains 400 mg of quercetin and adds 82.5 mg of bromelain, an enzyme derived from pineapple. Bromelain might even help improve the bioavailability of the quercetin. Plus, it adds to the overall anti-inflammatory effects of the formula.
A bottle contains 120 vegetarian capsules. Plus, the supplement is non-GMO and vegetarian/vegan-friendly, catering to various dietary preferences. It is also kosher certified and free from common allergens such as yeast, wheat, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients.
This is an affordable product from a trusted, GMP-certified brand. Overall, this is a solid choice. The brand is known for its rigorous testing standards and manufacturing processes.
Bluebonnet Nutrition Super Quercetin contains 250 mg per capsule with vitamin C, rose hips, acerola, citrus bioflavonoids, hesperidin, rutin, and pineapple bromelain. These are all anti-inflammatory compounds, so the “super quercetin” angle is that it includes more than just quercetin to fight inflammation.
Competitively priced, this is a great quercetin supplement with extra immune system boosts. As mentioned, bromelain might improve bioavailability and the same goes for Vitamin C. It gives you more bang for your buck.
It’s vegan, kosher, and gluten-free. A bottle contains 60 capsules.
Bluebonnet Nutrition is known for providing high-quality, non-GMO ingredients and manufacturing according to strict quality standards.
Thorne has another quercetin product that deserves your consideration.
It’s the same as their quercetin phytosome product as it contains 250 mg of Quercetin Phytosome. But that is not all. What sets it apart is that it also contains 100 mg of bromelain. As mentioned, this is an immune-boosting ingredient and potentially a bioavailability booster. It’s a great combo.
Overall, it may help with managing seasonal allergies and supporting respiratory health.
However, it’s slightly pricier per bottle for the added bromelain, so I’d go for Thorne’s simple quercetin phytosome product – #4 on our list.
Another benefit of quercetin supplements is their anti-allergy benefits. Quicksilver Scientific places this benefit at the forefront of their patent-pending quercetin product called Hista-Aid.
Histamines are chemicals in the body that, in many people, cause allergies. Some research has shown that quercetin prevents the production and release of histamine. In turn, this improves allergy symptoms.
The dose is smaller, with only 16 mg of quercetin per serving (four sprays). But it is a nanoemulsion liposomal product, so it has better bioavailability.
Other ingredients support the immune system, like luteolin, Diindolylmethane (DIM), and vitamin C.
Quercetin and luteolin are bioflavonoids that work together to regulate mast cells in the immune system.
It comes in a 1.7 fl oz (50 ml) fruity-flavor liquid.
Quicksilver is GMP-certified and makes only high-quality, science-based solutions for health and wellness.
Solgar’s Quercetin Complex with Ester-C Plus is a unique synergistic formula with an array of immune-boosting ingredients.
It combines the potent bioflavonoid quercetin with Ester-C Plus, a pH-neutral, non-acidic form of vitamin C that is gentle on the stomach. It also features bromelain, a natural enzyme derived from pineapple, enhancing the supplement’s effectiveness.
The capsules are made with vegetable cellulose, ensuring a high-quality product free from gluten, wheat, dairy, soy, yeast, sugar, and artificial ingredients.
You can purchase 50 capsules with 250 mg of quercetin for a great price at iherb, making it one of the best capsule-based supplements.
Jarrow Formulas offers a high-quality Quercetin supplement. It provides 500 mg of this potent bioflavonoid in each vegetarian capsule, the highest dose on our list.
Jarrow Formulas is known for producing high-quality supplements. Their products are manufactured in facilities that adhere to Good Manufacturing Practices (GMP), ensuring the highest quality and safety standards.
If you want to take higher doses, which most studies use, investigate this option.
As a bonus, we wanted to highlight the best BULK quercetin supplement.
PureBulk offers Quercetin Dihydrate, derived from the pagoda tree and standardized to over 98% purity.
Each serving contains 600 mg of quercetin.
You can buy it in capsules or powder, but the powder is more affordable. They have various sizes, but their starting point of 25 grams is already a better deal than any other product on the list.
However, it’s an unflavored powder, so mix it in a smoothie, shake, or glass of juice.
PureBulk supplements are tested by accredited third-party labs in the USA to ensure their identity, purity, and potency. Plus, customers can request a copy of the test results.
Here are the factors that went into our decision-making process.
As we’ve mentioned, regular quercetin has poor bioavailability. This means you’re not actually absorbing most of the quercetin from regular supplements.
That’s why our top products have liposomal or phytosomal delivery mechanisms. The quercetin is embedded in phospholipid molecules, acting as a protective barrier to guide it through your digestive tract. Of these two options, we’ve seen more convincing research on liposomal delivery, in particular, which is the case with Renue’s LIPO Quercetin.
We prioritize companies that are third-party, cGMP certified. However, some companies still skimp out on strict quality standards. That’s why we gave a nudge to companies that go above and beyond by manufacturing in FDA-approved facilities and displaying the purity results of the products online.
We like companies with nothing to hide.
All else being equal, it makes sense to buy the less expensive product. We factored in the cost with the number of servings, product quality, etc.
While liposomal delivery mechanisms can push the prices up, there are lower-cost supplements that are still effective.
Other products include other immune-boosting ingredients. We consider the impact of these other ingredients in our list.
Quercetin is a bioflavonoid compound found in fruits, veggies, and wine, though it’s especially abundant in blueberries, capers, onions, apples, and more. In fact, here’s a nice little chart from this study on quercetin.
However, it may also depend on whether the food is organically grown vs. chemically grown – organically grown tomatoes had almost 80% more quercetin. Maybe it’s time to start shopping in the organic section.
Basically, it’s a thing in healthy foods that makes them, well, healthy. In fact, diets high in bioflavonoids like quercetin may offer better protection against disease.
But quercetin offers more than just its antioxidant properties. Recently, there’s been a lot of talk and emerging research on its role as an anti-aging supplement, albeit different from other anti-aging supplements like NMN and berberine. It may also present anti-cancer, anti-inflammatory, pain relief, and anti-viral capabilities — which we are just now learning more about.
If you’re pounding blueberries and tomatoes, you’re getting a good amount of quercetin, among other health-boosting enzymes and ingredients.
But being beneficial and being useful as a dietary supplement are two different questions.
In the case of quercetin, most systemic reviews look at the benefits of quercetin supplementation.
So, always eat your fruits and vegetables. If you’re having a hard time, a quality greens powder supplement can help you cover your bases. Yet, a quercetin supplement on top of that may still be worthwhile.
The research on quercetin is quite extensive. However, it doesn’t demonstrate show-stopping benefits in all cases. Specifically, there’s a big difference in cell-cultured versus living studies.
Cell studies of quercetin often show amazing results, but they don’t carry over to humans or other animals.
One of the main reasons for this is that quercetin has low oral bioavailability.
If quercetin could magically appear in your blood, the benefits would automatically translate.
In short, quercetin supplements must focus on bioavailability. Otherwise, the quercetin won’t make it into the bloodstream.
All the products on our list focus on optimizing bioavailability, either via liposomal or phytosomal delivery mechanisms or by pairing quercetin with other bioflavonoids.
Quercetin is an antioxidant and anti-inflammatory compound with countless potential health benefits.
Allergy symptoms – sneezing, runny nose, itching, watery eyes, hives, and rashes – are a result of an inflammatory chemical called histamine, produced to rid allergens from the body.
Unfortunately, we live in a world packed with outdoor and indoor allergens, air pollution, and cities growing the wrong sex of trees (Toronto, I’m looking at you). Even diet can impact allergies.
Current research suggests that phytochemicals, like quercetin, may play an immunomodulating role in allergies. It may even stabilize mast cells, the guys that release histamine during allergic reactions. Basically, it may act as a natural antihistamine. The anti-inflammatory properties may also reduce swelling and inflammation associated with allergies.
Similarly, quercetin may support asthma, hives, and other conditions.
Population studies suggest a diet rich in quercetin correlates with better cholesterol levels. However, these are correlational population studies, so we need good human research.
A review study of all the available research showed that quercetin supplementation can support those with high blood pressure (hypertension). They concluded this at a dose of 500 mg per day.
As a downstream effect of its other benefits – like reducing inflammation, blood pressure, and blood glucose – quercetin may support heart health.
This study found quercetin supplements made from onion extract may significantly reduce cardiovascular disease risk in male smokers.
Quercetin is NOT approved as a treatment for any diseases. However, in test tube studies, quercetin and other flavonoids have helped to prevent cancer and tumor growth.
Quercetin is a powerful compound that protects our bodies against inflammatory reactive oxygen species that can damage our cellular and genetic structures.
Due to its anti-inflammatory properties, quercetin may support those with arthritis. This study on women with RA showed that 8 weeks of 500 mg of quercetin daily reduced their symptoms.
Here are some of your common questions about quercetin answered.
Flavonoid is just one of those words we pretend to understand, right?
Don’t worry, nothing to be embarrassed about here. Flavonoids are compounds found in fruits and vegetables. They’re grouped together because of their antioxidant properties.
Yes, quercetin is particularly abundant in fruits and vegetables such as apples, onions, berries, grapes, and capers. Other good sources include green leafy vegetables, tomatoes, broccoli, and green tea.
However, the concentration of quercetin varies based on ripeness and how it’s prepared or processed. Incorporating a diverse range of these foods into your diet naturally increases your quercetin intake.
That said, you’re unlikely to get a therapeutic dose (like those used in clinical studies) from diet alone. If you’re looking for more potent health benefits, a supplement may be worthwhile.
Quercetin isn’t an exercise supplement, but, like most antioxidants, it may help you perform better and recover if used as part of an overall healthy lifestyle.
This 2011 review found that quercetin may improve performance and capacity (VO2max) during endurance exercise.
There’s a lot of nonsense on the internet about what helps with weight loss. But there’s no quick fix, and quercetin isn’t likely to help you shed pounds.
Overall, effective weight loss depends on good nutrition, regular exercise, quality sleep, stress management, and a calorie-controlled diet.
That said, we wrote a whole article on the truth about quercetin and weight loss.
Quercetin has antioxidant properties, which might protect testosterone-producing areas in men, like the testes, from oxidative damage. That said, no convincing evidence suggests that quercetin will boost testosterone levels in humans.
For more info on this, check out our article “Quercetin and Testosterone: Does This Antioxidant Increase T?”
Quercetin is generally safe. The most common side effect is an upset stomach or headache.
When you take quercetin, start at a modest dose to let your digestive system adjust, and take it with food.
Very high doses may damage your kidneys. However, if you’re following the directions of the supplement, this won’t be a problem. But you probably shouldn’t take quercetin if you have a kidney disease.
As always, talk to your healthcare provider (and don’t trust strangers on the internet) before taking any supplement, including quercetin.
Fisetin and quercetin are both flavonoids. Like fisetin, quercetin has antioxidant and anti-inflammatory properties. It may also have other health benefits, from controlling blood sugar and reducing swelling to preventing heart disease and fighting against cancer. Yet, fisetin has higher senolytic abilities than quercetin.
This means fisetin might be a better choice for eliminating senescent cells.
Quercetin may act as an ionophore for zinc, a compound that supports its absorption across cell membranes. Plus, both compounds may support immunity and reduce inflammation. Plenty of animal studies have looked at using these nutrients together.
That said, we need more clinical research to show the effects of taking quercetin with zinc.
No. No, it’s not. Wine has trace amounts of quercetin. Nothing significant. Do not let clickbait articles convince you that wine is healthy.
Capsule form is by far the most practical and popular.
In terms of time of day, take quercetin first thing in the morning on an empty stomach. But you may need to start taking it with food until you know if it upsets your stomach.
The best quercetin supplement is the one you find convenient to take consistently, so use the dosage and form that matches your needs and preferences. Our list has plenty of bioavailable options.
The optimal daily dose depends on individual health goals and conditions. For general health purposes, studies often use 500 to 1000 mg per day. That said, if you’re using a liposomal supplement, like many on our list, the doses are typically much lower because the bioavailability (how much you absorb and use) is better.
Quercetin may affect the way the body metabolizes various drugs. For example, quercetin may interact with some types of antibiotics, cancer medications, and blood thinners.
Due to these potential interactions, consult with a healthcare provider before starting quercetin supplements, especially if you are on medication or have a medical condition.
The mechanism is complex, but the concept is simple. Basically, as we age, our body builds up senescent cells. These are cells that have run amok. They start misbehaving and bullying other cells. They’re like that kid in high school who used to be cool but then went off the rails and became a total menace in the classroom.
The point is that quercetin can clear out senescent cells. We see this in several studies, including this 2021 paper in Nature. It can also block the activation of inflammatory genes and proteins while promoting immune function.