This polyamine (a fancy organic chemistry term, but I just used it to sound smart) has possibly the best origin story of any supplement ever.
Anthony Van Leeuwenhoek (the guy who invented the microscope) discovered it in the 1600s when he decided to put sperm, presumably his own, under a microscope and look at it.
Yes, that’s the actual story.
Fortunately, today we don’t derive spermidine from sperm. We derive it mostly from wheat germ, which is much easier to produce, for a lot of reasons I probably don’t have to say.
So here’s the T (as the cool cats say) on spermidine supplementation.
Simply, spermidine may lengthen our lifespan, which it has done in yeast, worms, mice, and human immune cells. For example, this study in Nature showed exactly that.
These types of experiments are a bit tricky to do on humans, as they take about a century, but there’s compelling research to suggest that it carries over.
As mentioned, this is what all the buzz of spermidine is about. Research has shown that our spermidine levels begins to decrease around age 25-30.
Research indicates that our own spermidine levels start to decrease from approximately 25-30 years of age.
Other epidemiological research (that is, studies on populations), showed that people who ate more spermidine-rich foods averaged a life expectancy of five years longer.
Another recent study showed that many centenarians have spermidine levels similar to that of a young person, also suggesting that it plays a role in longevity.
As mentioned, spermidine has already increased the lifespan of other species.
Since “aging” is so broad, though, we’ve also seen other health and performance benefits from spermidine.
A 3-month study showed that spermidine supplementation improved memory in older people with dementia.
Clinical trials on healthy older adults have also shown memory improvements. All of this suggests that spermidine supplementation may slow down cognitive decline.
Whether that translates to increased cognitive performance in younger, healthy people remains to be seen. It also remains to be seen whether this improves conditions like Parkinson’s and Alzheimer’s.
In mice studies, spermidine has been suggested to improve cardiovascular health. This has also carried over to human population studies, but we still don’t have good research on humans yet. Nonetheless, we’re investigating more whether spermidine could reduce the risk of cardiovascular disease.
One of the proposed mechanisms for this is that spermidine may increase the number of mitochondria in heart cells.
Spermidine supports cellular respiration, which leads to increased mitochondrial content in heart cells.
While this research is very early, a study on macrophages and zebrafish (sounds like a fun sudy) showed that spermidine reduced inflammation and oxidative stress.
A lot of these benefits need more research. All of them, really. But they’re all pointing in a similar direction: if your goal is to live a longer, healthier live, a spermidine supplement may support you in that.
(As for how it does this, learn more about how spermidine works on a cellular level in the FAQ section.)
In fact, most supplements are crap, because they’re not regulated by the FDA. So even if you’re excited about spermidine, make sure you grab it from a quality source.
Today we’re discussing the best spermidine supplements on the market.
Every product on our list is third-party tested, and many go well beyond this to ensure quality.
*Note: We do have affiliate links throughout this article, which means we receive a commission if you purchase from any of our links. This supports our mission to bring complicated health and fitness info in an entertaining package. And it keeps us from putting up annoying things like banner ads. Those suck.
Best Overall: Renue by Science LIPO Spermidine
Highest Quality: LongevityLabs SpermidineLife Extra+
Renue by Science LIPO Spermidine stands out for a few reasons.
First, is the overall quality. Renue has a commitment to producing some of the best longevity products out there. All of their products are products in FDA-approved facilities. They even display their lab results of every batch, so you can ensure their products for purity.
Second, spermidine on its own is known for having poor bioavailability. That may not matter in yeast cell studies, but to humans, it sure does. Renue’s spermidine use a liposomal delivery mechanism to improve bioavailability.
This is when the spermidine molecules have a protective lipid coating that helps them survive our intense digestion environment and make it into our bloodstream.
Third, Renue LIPO Spermidine is a great value. Because this is such a cutting-edge supplement, a lot of products are still very expensive. Renue’s product, in contrast, is more affordable, especially when compared per gram. With 4mg per serving, it has the best combination of quality and value.
For all of these reasons, Renue LIPO Spermidine is our #1 pick.
In terms of overall quality, SpermidineLife® Extra+ from Longevity Labs is tough to beat.
Longevity Labs has an array of spermidine products developed in Austria. They use a specific, patented CelVio® complex that ensures a consistent and pure process. It’s also a natural manufacturing process, so their spermidine gets combined with other polyamines like spermine, as well as micronutrients, and doesn’t contain any synthetic ingredients.
Overall, simply, it’s among the highest quality spermidine companies out there, and they have the patents, process, and awards to back it up.
Their “Extra+” version contains a higher dose than the original (which we’ll talk about next), with nearly twice the amount of spermidine. Still it’s less than 2mg of spermidine overall, making it half the dose of what Renue offers.
Nonetheless, Longevity Labs SpermidineLife® Extra+ is a top-quality product. If cost is not an issue for you, then start here.
This is another very high-quality product from a cutting-edge research group. It has 1mg of spermidine per serving.
Primeadine also contains prebiotic fiber and resistant starch to support bacteria in the gut that produce spermidine. In that sense, they view their product as not just about exogenous spermidine, but about helping the body produce more spermidine naturally.
The reality is, between our top three products, all are super reputable companies with great products. In a lot of respects, we’re splitting hairs, and you can’t go wrong with LIPO Spermidine, SpermidineLIFE, or Oxford Healthspan Spermidine.
This is the original SpermidineLife® product. It’s a bit less pricey than their other version, but its dose is also smaller, with only 1mg per serving.
Double Wood provides the highest dose at the least expensive upfront cost on our list. They’re also manufactured in the USA and have the testing results of every batch displayed on their site.
This makes it a great option to start out taking spermidine. However, bioavailability is a question, since it doesn’t have other mechanisms like the other products on our list so far.
Primeadine also comes in a gluten-free version. Because spermidine is typically derived from wheat germ extract, premium spermidine extracts typically contain gluten. This is the only exception from a high-quality brand.
It contains 1.2mg of plant-derived spermidine with the added ingredient nobiliten, which also may enhance autophagy.
Because it comes from different plants, it’s a naturally occurring source of vitamin D2, vitamin K, folate, vitamin B12, biotin, pantothenic acid, iron, and lutein.
For a gluten-free option, it’s by far your best bet.
Here are the main factors that went into our rankings. Of course, what may be the best product varies from person to person depending on goals, budget, and more.
So take it all into consideration when making your decision.
Some products contain various delivery mechanisms that can increase the bioavailability of spermidine, like Renue’s LIPO Spermidine, which has a protective liposomal layer around the spermidine molecule.
We also weighed the strictness of the testing of the product, and the company’s commitment to longevity. For example, Spermidine Life is a company deeply involved directly with the research. There’s little doubt about the quality and efficacy of their products.
Of course, money is a factor for most of us. While I love Spermidine Life’s quality is much more expensive than other products.
Renue is #1 also because they find this perfect balance. They maintain very high quality and strict testing, while also lowering their prices to be more affordable, even if that means cutting into their own margins.
The most well-understood is spermidine’s ability to increase autophagy.
Autophagy is one of those fancy science words that nobody really understands, so it’s going to get its own question.
Basically “increased autophagy” means that the cell’s clean-up crew is hard at work.
Imagine cells without any janitors, street cleaners, or good citizens picking up trash. This is a cell with low levels of autophagy. Now imagine that a cell is well-kept and constantly looked after by a team of workers. That’s a cell with high levels of autophagy.
This is stimulated by a few well-known longevity pathways, like the suppression of mTOR.
Simply, research has shown that high levels of spermidine mean more autophagy.
Second, research has suggested that spermidine can adjust epigenetic expression. As the theory for longevity goes, part of what causes aging is genes we onced “expressed” when we were young, get suppressed as we age.
By turning back the clock on the gene expression, we can slow down (or even reverse) aging. Spermidine may enhance this, per recent studies.
Yes. One study on the polyamine content of foods said, “Spermidine content was high in dry soybean, chicken liver, green peas, corn, shellfish, and blue cheese.” The Japanese soybean dish natto is a great option also, and you can get it at most boujie poke bowl places these days.
Another option, instead of the standard supplement route, is to buy wheat germ. This is definitely a much more economical route, if you’re on a tight budget.
For example, you can buy this simple wheat germ product from Bob’s Red Mill for under 5 bucks. You’ll have to find a way to use it for cooking, but it contains ample spermidine.
Yes. In fact, almost all of the studies look at daily supplementation. Every product on the market suggests daily use, and there isn’t any downside to regularly taking it compared to sporadic use.
Because spermidine comes from wheat germ, most spermidine products on the market contains a small amount of gluten (usually no more than a few miligrams). Nonetheless, wheat germ-derived spermidine supplements are contraindicated if you ahve celiac disease.
If you need to avoid gluten, we recommend Oxford Healthspan’s Gluten-Free Spermidine.
This is a question for your organic chemistry professor, not me. But basically they’re not proteins, but they have amino groups, so chemically they have some stuff in common. More improtantly, polyamine synthesis is crucial for cell renewal, growth and repair, and that’s where spermidine comes in.