The 5 Best Apigenin Supplements (2023) Reviewed and Compared

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Apigenin is a flavonoid and antioxidant most abundantly found in chamomile tea. In fact, apigenin is responsible for most of chamomile’s researched health benefits, like improving sleep and decreasing stress.

How Apigenin Can Improve Health and Extend Life

However, apigenin has become increasingly popular not just for improving sleep, but also for potentially extending our lifespan and keeping us healthier.

I’ve written a lot about life extension, so I won’t go in too deep here. Basically, apigenin increases lifespan through two main mechanisms.

  1. Apigenin decreases CD38 (fancy science term). CD38 has been linked to low NAD levels, and as we talked about in the article on the most popular NAD precursor, NMN supplementation, high NAD levels keep cells healthy.
  2. Apigenin eliminates senescent cells. These are “zombie” cells, which have lost their “identity” as cells, and is one of the leading theories right now to describe how we age.

In fact, apigenin research has looked at it for everything from Alzheimer’s disease, to depression, to insomnia. That’s the power of looking at ingredients that improve the human body as a whole, and not just specific conditions.

I think by looking into apigenin supplements now, you’re ahead of the curve of what’s going to be much more popular in a few years, as more and more research comes out. It’s also a simple antioxidant, so there isn’t much downside. I don’t think it’s possible to drink too much chamomile tea, to be completely honest.

With that said, not all supplements are created equal, so if you want to try apigenin supplementation, then make sure you’re selecting a product from a trusted brand. Every product on our list is GMP (good manufacturing practices certified) and third-party tested. Some companies even go above and beyond this.

*Note: We do have affiliate links throughout this article, which means we receive a commission if you purchase from any of our links. This supports our mission to bring complicated health and fitness info in an entertaining package. And it keeps us from putting up annoying things like banner ads. Those suck.

Without further ado, here’s our list of the best apigenin supplements of 2022.

1) Renue by Science LIPO Apigenin

renue by science lipo apigenin

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Renue by Science, simply, is the best longevity brand around. They specialize in supplements formulated for life extension and health extension, and their apigenin product is no exception.

First, apigenin on its own doesn’t have great absorption or bioavailability. Renue’s product is what’s called liposomal. This means the apigenin molecules are surrounded by lipids that are designed to protect the apigenin during the digestive process so that it can make it to the bloodstream.

They’re also in our top spot because they go behind cGMP certification. They display the lab results of every batch of their products, and manufacture in an FDA-approved facility. In terms of inspiring confidence through transparency, Renue shows us why they’re one of the best brands out there.

Each bottle contains 90 capsules with 35mg of apigenin, and you can get 10% Renue LIPO Apigenin through our link.

2) Codeage Liposomal Apigenin

codeage liposomal apigenin

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Codeage also has a top-tier liposomal apigenin product. While they don’t have testing as strict as Renue, their product is a better value. They also have 90 capsules per bottle but with 50mg per capsule for just $30 a bottle.

They’re cGMP certified and manufactured.

3) Double Wood Supplements Apigenin

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For more servings at a lower price point, Double Wood Supplements provides 50mg of apigenin for just $25. And each bottle comes with 120 servings.

The downside is that, unlike Renue and Codeage, their product is not liposomal, nor does it contains

Double Wood is one of the most trusted brands in the health space, and also display their lab results.

4) Life Extension Senolytic Activator

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The Senolytic Activator from Life Extension contains 36 servings for $19 with 50mg of apigenin. It’s more expensive on a per gram basis, but this product does contain other ingredients with interesting longevity research. Notably, it contains quercetin, which we’ve looked at in our guide on the best quercetin supplements.

This product also contains theaflavins, another antioxidant compound.

5) Life Extension Herbal Sleep

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If you’re looking specifically for an apigenin product to support sleep, then Herbal Sleep contains additional ingredients, including honokiol (magnolia bark) and lemon balm extract.

The apigenin in this product comes from chamomile extract, for a total of 25mg of apigenin per capsule.

Each bottle contains 30 capsules for $18.

How We Ranked

Here are the factors we looked into when selecting products for our list.

Company Quality

For us, the most important aspect of supplements is choosing companies that we can trust and who have strict quality standards. Because supplements aren’t regulated by the FDA, supplement companies can (and do) put all kinds of shady ingredients in supplements.

Every product on our list is GMP certified, but we gave an edge to companies who go beyond that, like Renue, who manufactures in an FDA-approved facility.


As mentioned, apigenin doesn’t have the best absorption. That’s why Renue and Codeage’s products take our top spot. They contain liposomal capsules, which protect the apigenin molecules and increase absorption.

Cost and Dose

Finally, of course we factored in the amount of apigenin, how many servings it came with, and what it cost. All else being equal, we gave a nudge to the more cost-effective product.

Extra Ingredients

Life Extension’s products made our list because they even contain more than just apigenin, to further support life extension and sleep.

For more on life-extension ingredients, we have written similar guides on the best NMN supplements, the best quercetin supplements, and the best berberine supplements.

About the Author

David is a writer and strength coach and co-owner of Roman Fitness Systems. In addition to helping run RFS, he's also the head editor for, the official website of the Strength and Conditioning Association of Professional Hockey. You can also check out his Instagram, he's pretty easy on the eyes.

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