Vitamin C is one of those health supplements that everyone has heard of. You probably have a tub in your medicine cabinet that comes out when you feel under the weather.
Vitamin C is more than just your friend when you have the flu. It’s a two-in-one nutrient, functioning as both a vitamin and a powerful antioxidant in numerous physiological processes. Every system in your body depends on vitamin C.
Ironically, it isn’t made in the human body. You must consume vitamin C every day to keep your levels up. There’s no way around it. Luckily, taking supplements makes it much easier to meet your daily goals. However, not all vitamin C supplements are created equal.
Today, we explore the health benefits of vitamin C and why liposomal vitamin C is better than conventional vitamin C supplements.
You’ll also find our list of the 8 best liposomal vitamin C supplements you can buy today.
Liposomal vitamin C is a lipid-based supplement that claims to be the most bioavailable form of vitamin C.
Liposomes are microscopic fat droplets that form a pocket around vitamin C to facilitate absorption. Because vitamin C is water-soluble, encasing it in a lipid bilayer improves absorption at a cellular level.
The lipids – known as phospholipids – are the same lipids that make up your cell membranes. Cells in the small intestine quickly bond to the liposomes and absorb the contents.
In short, the liposomal sphere acts like a VIP escort, safely guiding vitamin C through your digestive tract and delivering it directly to your cells.
Research suggests 30% of conventional oral vitamin C supplements are excreted via urine (and even more in people considered “poor absorbers”).
By almost all measures, liposomal vitamin C supplements have an advantage over regular vitamin C.
So, what’s so special about liposomal vitamin C?
Studies show liposomal delivery systems improve intracellular nutrient delivery. This study found oral liposomal vitamin C was 1.77 times more bioavailable than non-liposomal vitamin C. It raises vitamin C blood levels more than conventional supplements – as per research.
Higher bioavailability means you need a lower amount of vitamin C overall.
Liposomal supplements are non-invasive and safer compared to vitamin C IV treatments. As a bonus, liposomes provide your cell membranes with the raw materials they need to function well.
Supplementing with vitamin C (whether liposomal or not) may protect you from oxidative cell damage and inflammation by scavenging unstable free radicals in the body.
Let’s discuss some of the science-backed benefits of vitamin C.
Supporting your immune system is what vitamin C does well.
Vitamin C is concentrated in your white blood cells (the guys responsible for patrolling your blood and tissues looking for foreign invaders).
It may reduce the duration and severity of a common cold, as this study found. Interestingly, further research suggests vitamin C may prevent you from getting sick after bouts of intense physical exertion.
Liposomal vitamin C has an edge when it comes to immune health. This study found white blood cells absorbed more vitamin C from a liposomal product than a conventional supplement.
In sum, adding liposomal vitamin C to your supplement stack may prevent you from falling victim to every virus going around. Plus, if you do get sick, it may help you bounce back faster.
There’s a reason why eating vitamin C-rich fruits and veggies is associated with great-looking skin. Your skin contains high levels of vitamin C.
It’s a co-factor for the synthesis of collagen – a structural protein that gives your skin elasticity, strength, and suppleness. Vitamin C helps to form a collagen precursor, known as procollagen, in a process called hydroxylation.
Unfortunately, as with many things, collagen production declines with age. Excessive sun exposure, smoking, and pollution deplete the skin of vitamin C and contribute to collagen degradation.
To sum up, oral liposomal supplements (and topical vitamin C solutions) may slow down skin changes associated with aging.
As a potent antioxidant, vitamin C protects your blood vessels and cardiovascular system from oxidative stress. Research shows higher dietary vitamin C intake lowers the risk of cardiovascular disease.
A 2008 meta-analysis of 13 studies found taking at least 500 mg of vitamin C daily improved blood lipids. It significantly reduced “bad” low-density lipoprotein (LDL) cholesterol and triglycerides. Plus, there was a slight increase in the protective high-density lipoprotein (HDL) cholesterol.
By supporting collagen production, vitamin C also helps to maintain the elasticity of blood vessels as you age. This may reduce hardening of the arteries, which is exactly what this 2021 systematic review and meta-analysis found.
With all that said, let’s get into our list of the 8 best liposomal vitamin C supplements.
They’re made according to current Good Manufacturing Practice (cGMP) standards and thoroughly evaluated for potency and purity.
*Note: We have affiliate links throughout this article, which means we receive a commission if you buy from any of our links. This supports our mission to bring complicated health and fitness info in an entertaining package. And it keeps us from putting up annoying things like banner ads. Those suck.
Codeage Liposomal Vitamin C+ takes the top spot on our list. It’s a superb formula with advantages over other supplements on the market.
Each serving delivers 1500 mg of liposomal vitamin C (as ascorbic acid) with a synergistic blend of citrus bioflavonoids, quercetin, elderberry, and rosehip. Bioflavonoids may enhance vitamin C absorption because these nutrients exist together in plant foods.
As a bonus, you get 15 mg of zinc and 100 mg of alpha lipoic acid per serving. This powerhouse blend elevates the benefits of vitamin C for immune health, longevity, and skin health.
The formula contains phosphatidylcholine from non-GMO sunflower. Using sunflower makes it soy free, which is ideal for those with allergies.
This liposomal delivery system gets vitamin C directly into your cells with little risk of GI upset.
Another key benefit of this product is convenience. Codeage is one of only a few brands offering liposomal vitamin C capsules – most others come in liquid form. The capsules are easy-to-use and are a good option for those who prefer not to taste their supplements.
These high-dose vitamin C capsules are non-GMO, vegan, keto-friendly and free from dairy, gluten, soy, binders, artificial flavors, and additives.
A bottle of 180 capsules (a 2-month supply) costs $35.99. This is comparable to (or even more affordable than) other top liposomal vitamin C products. The suggested serving size is 3 capsules. However, the superior bioavailability means you can easily take 1-2 capsules per day and still get a therapeutic dose (and a bottle will last 1-2 months longer).
Finally, Codeage has strict quality and testing standards. All their products are US-made in cGMP-certified facilities. Plus, they use thorough third-party testing to confirm purity and potency.
For all these reasons, Codeage Liposomal Vitamin C+ is our #1 pick.
Seeking Health Optimal Liposomal Vitamin C is a close second. We’re super impressed with this third party-tested product.
It delivers 1000 mg of vitamin C (as sodium ascorbate and ascorbic acid) encased in phospholipids from non-GMO sunflower oil.The addition of sodium ascorabte buffers the formula, reducing the overall acidity.
It comes in a liquid form you can take alone or add to water or juice. The fruity pineapple and orange flavor makes taking vitamins fun again!
This product is ideal for people with allergies as it’s free from GMOs, eggs, gluten, dairy, peanuts, artificial colors, and additives.
It sells for $32.95 – just over $1 per serving of the highest-quality vitamin C. To top it off, they offer a 60-day satisfaction guarantee, so there’s no risk.
With Seeking Health, you know you are getting a pure, high-quality product made according to NSF-accredited cGMP standards.
Quicksilver Scientific Liposomal Vitamin C delivers 1000 mg of Quali®-C vitamin C (as sodium ascorbate) and 250 mg of phospholipids from purified sunflower lecithin.
The unique thing about this product is its clear consistency due to nano-sized liposomes. They easily bypass the digestive system and transport nutrients through cell membranes.
It comes in a fruity liquid flavored with all-natural citrus oils. It’s vegan, non-GMO, and free from dairy, gluten, sugar, and common allergens.
Quicksilver Scientific has some of the highest quality standards in the industry. All their products are US-made according to cGMP standards and go through thorough in-house and third-party testing.
The only downside is that a bottle only has 24 5 ml servings – less than a one-month supply.
Seeking Health is so serious about quality liposomal vitamin C that they offer more than one option.
A 5 ml serving of Optimal Liposomal Vitamin C Plus delivers 1,000 mg of vitamin C and 400 mg of phospholipids from non-GMO sunflower oil. Additionally, it contains a synergistic blend of bioflavonoids from rose hips, quercetin, and hesperidin.
It’s a great-tasting, easy-to-take, and all-around quality supplement.
If you don’t like capsules, we recommend the Codeage Liposomal Liquid Vitamin C Pouches.
Each convenient liquid sachet contains 1000 mg of the same high-quality vitamin C encased in 400 mg of non-GMO phospholipids. Plus, the formulation finishes off with vitamin E and bioflavonoids from citrus terpenes.
The liquid comes in a citrus vanilla flavor. It’s also vegan-friendly and free from sugar, gluten, dairy, soy, artificial colors, sweeteners, and preservatives.
A box of 32 sachets costs $49.99.
LivOn Laboratories are the OGs of liposomal supplements. Their cGMP-accredited Lypo-Spheric® Vitamin C was the first liposomal product I came across years ago. And I’m just as impressed with it today as I was then.
It comes in single-dose liquid sachets, which deliver 1000 mg of vitamin C encased in 1000 mg of phospholipids. The sachets are non-GMO, vegan, and hexane, gluten, sugar, and dairy-free.
Interestingly, LivOn Laboratories have subjected their product to double-blind, placebo-controlled studies. This study found 1-3 sachets daily increased skin firmness and reduced the fine lines and wrinkles in just 4 weeks. While this is impressive, the company sponsored the research (take it with a pinch of salt is what I’m saying).
Dr. Mercola also has a convenient capsule-based liposomal vitamin C supplement.
Each capsule delivers 500 mg of vitamin C with phospholipids sourced from non-GMO sunflower lecithin. It’s ideal for those who want a slightly lower dose.
You can choose between two sizes: 60 or 180 capsules.
Aurora Nutrascience is a cGMP-accredited leader in cutting-edge liposomal technology.
Their Mega Liposomal Vitamin C delivers 3000 mg of vitamin C per serving encapsulated in nano-sized liposomes from non-GMO phosphatidylcholine from soy lecithin.
The liquid is sugar-free and flavored with organic natural fruit flavoring and gluten-free stevia leaf extract.
The product is made according to strict manufacturing standards. But it’s not clear whether they use third-party testing.
We ranked these products, but we want you to decide on the best product for your needs. To do that, you need to understand how we ranked.
Here are factors we considered when researching the best liposomal vitamin C supplement.
The Food and Drug Administration (FDA) doesn’t regulate dietary supplements as it does pharmaceuticals. Unfortunately, dodgy companies flood the market with tainted supplements to make a quick buck.
We prioritize reputable companies that adhere to cGMP regulations and use independent testing.
Bioavailability is the name of the game with liposomal vitamin C supplements. All the products on our list use cutting-edge liposomal technology to enhance bioavailability.
The products have therapeutic doses ranging from 500-3000 mg per serving.
Liposomal vitamin C typically comes in liquid or gel form. We’ve also included capsule-based products for your convenience.
Improving your health and wellness shouldn’t put you out of pocket.
That said, liposomal products are more expensive due to the technology used in manufacturing. However, the upside is you need a lower daily dose.
We weighed the cost of each product against the number of servings, dose per serving, and overall quality to decide which products are the best value.
If you’re struggling with fatigue and weakness, your iron levels might be low. Without sufficient iron, you struggle to form hemoglobin, a protein in red blood cells that transports oxygen to every cell in the body.
Research suggests vitamin C supports the bioavailability of dietary iron. However, this may be more useful for vegetarians and vegans who consume non-heme iron, which is notoriously hard to absorb.
Gout is a painful condition. The build-up of uric acid crystals is excruciating, like tiny shards of glass piercing your joints. Ouch.
Interestingly, vitamin C may clear excess uric acid from your system, thus preventing a build-up. This study found taking vitamin C reduces the risk of developing gout.
Vitamin C is an essential coenzyme in the production of mood-boosting brain chemicals. This may explain why low vitamin C levels are associated with symptoms of depression.
However, we need more high-quality studies to confirm the effects of vitamin C supplements for mood support.
Severe vitamin C deficiency isn’t common in developed countries (most of us have access to fresh fruit and veg). While we may avoid deficiency, many of us still don’t get optimal levels of this essential nutrient. And it shows up in our levels of well-being.
Some of the signs of low vitamin C include:
In addition, you might need to up your vitamin C intake if you fall into any of these categories:
Yes! Citrus fruit, berries, tomatoes, broccoli, leafy greens, pineapple, kiwi fruit, papaya, and peppers are all a source of vitamin C.
But we don’t always eat as many fresh fruits and veggies as we should. Liposomal vitamin C is a convenient way to get a therapeutic dose quickly and support your overall well-being.
Vitamin C is an essential nutrient, with a recommended daily allowance (RDA) of 90 mg for men and 75 mg for women. This rises to 115 mg for smokers and 125 mg for pregnant or lactating women.
That said, experts believe this is the bare minimum to avoid deficiency.
The upper tolerable limit (UL) is 2000 mg per day. That said, the higher bioavailability of liposomal vitamin C means you don’t need to take as much to get the same health benefits. A dose of 500 – 1000 mg of liposomal vitamin C is ideal. However, you may need to take more when sick, under severe stress, or at risk of deficiency.
It’s best to take liposomal vitamin C on an empty stomach or between meals to enhance absorption.
If you take it in gel or liquid form, you can take it neat or mix it into water or juice to help it go down. However, don’t add it to hot liquids or blend (this can destroy the liposomes).
I like to take my liposomal vitamin C at the same time of day. This helps me avoid getting lackadaisical about taking my daily dose.
Liposomal vitamin C is generally considered safe for most people. High doses are associated with uncomfortable digestive symptoms. However, these symptoms stop as soon as you lower the dose.
You are less likely to experience side effects from a liposomal form because the increased bioavailability means you don’t need to take a high dose. Overall, it’s easier on your digestive system.
Vitamin C is water-soluble, so you pee out any excess. There’s little risk when taking high doses – the worst that can happen is an upset stomach. That said, please consult your healthcare professional before taking any new supplement.
For optimal potency and freshness, store liposomal vitamin C in the fridge.
Liposomal vitamin C is a tried-and-tested wellness supplement that offers high absorption and bioavailability. It’s simple to take and comes with minimal risk.
However, liposomal Vitamin C products are not a replacement for a healthy, whole-food diet.